Terminalia Chebula Fruit Extract

Terminalia Chebula is an Ayurvedic plant native to South Asia. As an edible superfruit, it’s traditionally used as a dietary supplement to treat health conditions like diabetes and arthritis – earning it the nickname “The King of Medicine” in the region. In skin care, Terminalia Chebula fruit extract can be used in topical applications as well as oral supplements to provide holistic skin benefits and gut homeostasis. Synastol® TC is a natural and well-defined extract of Terminalia Chebula for topical applications and oral supplementation.

Terminalia Chebula Fruit Extract



Direct Extraction


  • Extracellular matrix builder by stimulating Matrisome gene & collagen proteins
  • Regulator of circadian rhythm genes
  • AMPK activator which is considered to be a longevity protein kinase and modulate multiple longevity pathways
  • Multitargeted anti-aging product – Antiglycation and Glycation reversal
  • Cascading and broad-action super fruit antioxidant
  • Significantly reduces oxidative stress induced by urban dust and blue light
  • Significant reduction in pro-inflammatory biomarkers – IL-6 and IL-8
  • Reduces and repairs barrier dysfunction
  • Cascading and broad-action super fruit antioxidant
  • Multitargeted anti-aging product – Antiglycation and Glycation reversal

Terminalia Chebula Fruit Extract Research

Cosmetics & Toiletries, Article # 21835343, 2015

RK Chaudhuri, Z Lascu & F Marchio

Terminalia Chebula Fruit Extract

Synastol® TC

The Holistic Solution to Pollution & Blue Light-Induced Skin Damage with Anti-Aging Benefits

Get Your Gut In the Game of Skin Beauty

FAQs About Terminalia Chebula Fruit Extract

Terminalia Chebula is an Ayurvedic plant extract from South Asia. It has a long history of human use and is a frequently prescribed herbal remedy in Ayurveda for strengthening and nourishing the body. Terminalia Chebula is highly revered for its purifying attributes.

Terminalia Chebula is a deciduous tree that grows up to nearly 100 feet tall with a trunk up to 3 feet and 3 inches in diameter. Terminalia Chebula produces small, greenish-yellow fruit that are highly valued for their medicinal properties.

Yes, Terminalia Chebula is commonly referred to as Haritaki, which is the Sanskrit name for the plant.

Terminalia Chebula is native to South Asia. Specifically, it can be found in India, Sri Lanka, Bhutan, Nepal, Bangladesh, Myanmar, Cambodia, Laos, Vietnam, Indonesia, Malaysia, Pakistan and Thailand.

Terminalia Chebula offers various health benefits according to traditional medicine systems like Ayurveda. Some of the potential health benefits include digestive health, antioxidant properties, anti-inflammatory effects, immune support, detoxification, cardiovascular health, anti-microbial activity, and neuroprotective effects. However, while Terminalia Chebula has been used for centuries in traditional medicine, scientific research continues to explore its effects and confirm its potential health benefits.

Terminalia Chebula fruit extract is a concentrated form of the active constituents found in the fruit of the Terminalia Chebula. It is available commercially for topical or oral use as Synastol® TC.

Synastol® TC is the first topical grade Terminalia Chebula fruit extract product available commercially from Sytheon. Synastol® TC was obtained from the edible fruits of Terminalia Chebula through a water-based process. The product has been standardized against total hydrolysable tannins: ≥50%, chebulinic acid: ≥20%, and chebulagic acid: ≥ 10%.

Terminalia Chebula fruit extract is a multifunctional and globally approved skin care ingredient that can be used for anti-aging, anti-pollution, and microbiome diversity applications. It is clinically proven to mitigate multiple signs of aging, including wrinkles, fine lines, and under eye areas. It is also clinically proven to reduce oxidative stress from pollution and blue light, reduce inflammatory stress, and improve the skin barrier and hydration. Finally, Synastol® TC (Terminalia Chebula fruit extract) can be formulated as an oral supplement that provides skin benefits while improving gut homeostasis.

Synastol® TC (Terminalia Chebula fruit extract) is a high-performing active that provides safe, positive results. Here are some key results from clinical studies using Terminalia Chebula fruit extract in a topical formula:

  • Improvement in aging signs within 4 weeks and continued improvement until week 12
  • Improvement in overall eye appearance
  • Improvement in pigmentation attributes
  • Significant reduction in under-eye dark circles

When used as an oral supplement, Synastol® TC (Terminalia Chebula fruit extract) has shown:

  • Greater alpha diversity and increased amounts of favorable gut bacteria and phages
  • Increase in short chain fatty acids (SCFs, epigenetic regulator)
  • Increase in relative abundance of Akermansia muciniphila, a powerhouse probiotic, involved in human metabolic homeostasis and disease progression
  • Modulater of bile acids which shape the microbiota composition by activating host signaling pathways that maintain gut homeostasis
  • 33% decrease in sebum excretion rate
  • Statistically significant decrease in cheek erythema
  • Statistically significant decrease in wrinkles

Terminalia Chebula fruit extract is considered a supercharged antioxidant with multifunctional benefits. It is a photostable cascading antioxidant without prooxidant activity.

As a broad-action antioxidant with an ORAC (Oxygen Radical Absorbance Capacity) value superior to major hyperfruits, Terminalia Chebula fruit extract (Synastol® TC) has been shown to reduce the formation of ROS (reactive oxygen species) and lipid peroxidation caused by the sun, pollution and blue light.

The applications of Terminalia Chebula fruit extract are promising. Today, customers can incorporate the active into their skin care routine with hydrating night creams, body lotions, and even scalp treatments. Synastol® TC is also available as a nutritional supplement to improve gut homeostasis and promote beauty from the inside out. Learn more about this new application here.

Terminalia Chebula fruit extract (Synastol® TC) has a yellow to beige powder appearance. It can be formulated into lotions, toners, creams, and serums. When used as an oral supplement, an ultra-concentrated and standardized bioactive powder form of Terminalia Chebula is delivered in a hard gelatin capsule.

The recommended use level of Synastol® TC fruit extract is 0.5 to 1% for topical use. For use as a nutritional supplement, the appropriate level is 250 mg in a capsule twice a day.

Terminalia Chebula fruit extract should be stored in the original sealed container at +10 to +30°C. Avoid exposure to light, heat, and moisture. It remains stable for over three years.

Yes. Terminalia Chebula fruit extract is well-tolerated by most skin types. Clinical studies have shown clear benefits for the skin. Please review research about Terminalia Chebula fruit extract here.