Atopic dermatitis (eczema) is a chronic condition that makes your skin red/ itchy, and flares occur periodically due to epidermal barrier disruption to the TH-2 mediated inflammation process. It is common in children but can occur at any age. Topical emollients are a cornerstone of management of disease.


This study evaluated efficacy of two plant derived oil derivatives, isosorbide di-(linoleate/oleate) (HydraSynol® IDL) and isosorbide dicaprylate (HydraSynol® DOI), using AD-like tissue culture models. Treatment of reconstituted human epidermis with cytokines led to significant reduction in inflammatory and neurogenic pruritus mediators. These results demonstrated synergistic anti-inflammatory mechanisms of isosorbide fatty acid diesters in AD-like skin models. These findings highlight the multifunctional advantages of HydraSynol® IDL and DOI as therapeutic candidates to treat Atopic Dermatitis.


Current study complements an earlier study published by the company (J Investigative Dermatology, 2021, 141:1416-1427) on IDL which has shown to stimulate pro-differentiation gene expression to restore the epidermal barrier and improve skin hydration.


Swindell, W.R.; Bojanowski, K.; Chaudhuri, R.K. Isosorbide Fatty Acid Diesters Have Synergistic Anti-Inflammatory Effects in Cytokine-Induced Tissue Culture Models of Atopic Dermatitis. Int. J. Mol. Sci. 2022, 23, 14307. https:// doi.org/10.3390/ijms232214307

About Sytheon

Sytheon is an innovative research-based company committed to developing high performance active ingredients for personal care since 2006. Every product in Sytheon’s portfolio is inspired by nature and are scientifically and clinically validated to improve the health and beauty of the skin. Sytheon features ingredients that combat aging and pollution, promotes well aging and hydration, provides solutions for problem skin, and augments skin defenses against UV or blue light.

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