Sytheon Announces New Peer Reviewed Publication on Synoxyl® AZ

RK Chaudhuri, T Meyer, S Premi, D Brash, Acetyl Zingerone: An efficacious multifunctional ingredient for continued protection against on-going DNA damage in melanocytes after sun exposure ends, International J Cosmetic Science, 2019 Sep 20. doi: 10.1111/ics.12582. Open access.

Abstract:

Damage to DNA is arguably the most important type of photodamage initiated by sun exposures. Recent research by Yale University has shown that significant levels of cyclobutane pyrimidine dimers (CPDs) in DNA continue to form in melanocytes for several hours in the dark after exposure to ultraviolet radiation (UVR) ends. In collaboration with Yale University scientists, Sytheon has demonstrated utility of a new multifunctional ingredient, 3-(4-hydroxy, 3-methoxybenzyl)-pentane-2,4-dione; INCI Acetyl Zingerone (AZ) to protect melanocytes against CPD formation after UVR exposure ends.

Even when added immediately after irradiation, AZ significantly inhibited on-going formation of CPDs in melanocytes after exposure to UVA. Incubation with AZ before irradiation decreased intracellular levels of UVA-induced ROS formation in keratinocytes. Compared with α-tocopherol, the molecular structure of AZ endows it with significantly better photostability and efficacy to neutralize free radicals (٠OH, ٠OOH), physically quench singlet oxygen (1O2) and scavenge peroxynitrite (ONOO-).

These results designate Synoxyl® AZ as the best-in-class broad-action antioxidant with both quenching and scavenging properties. Synoxyl® AZ has a strong potential to extend photoprotection of traditional sunscreens and daily skin care products over the first few hours after sun exposure ends.

For more information, please send your inquiry to info@sytheonltd.com

Bakuchiol is a multifunctional ingredient that offers various benefits to skin care customers. It's even more powerful when paired with other actives.
Sytheon recently published breakthrough research on acetyl zingerone and tetrahexyldecyl ascorbate’s effectiveness on skin photoaging.
Learn how Bakuchiol works in skin care formulas – and how well it works for your customers – in this helpful guide for beauty brands.
Bakuchiol is known as a natural alternative to retinol. What else do skin care and beauty brands need to know about it? Here’s a complete guide to Bakuchiol 101.
Synastol® TC is a natural, safe ingredient that can now be used as a nutritional supplement, providing holistic benefits for customers.
5 Ways to Formulate with Bakuchiol for Even More Benefits

5 Ways to Formulate with Bakuchiol for Even More Benefits

Bakuchiol is a diverse, multifunctional ingredient that offers game-changing benefits to your customers, and it’s even more powerful when paired...

by Dr. Ratan K. ChaudhuriApril 29, 2024
Read More
How Bakuchiol Works: Formulation Tips for Brands & Results

How Bakuchiol Works: Formulation Tips for Brands & Results

Bakuchiol promises great benefits to customers of any skin type. How does it work? Here’s how to formulate with Bakuchiol...

by Dr. Ratan K. ChaudhuriMarch 28, 2024
Read More
Bakuchiol 101: Everything Skin Care & Beauty Brands Need to Know

Bakuchiol 101: Everything Skin Care & Beauty Brands Need to Know

Bakuchiol is known as a natural alternative to retinol. What else do skin care and beauty brands need to know...

by Dr. Ratan K. ChaudhuriMarch 13, 2024
Read More
Where Does Bakuchiol Come From? [Short Guide for Beauty Brands]

Where Does Bakuchiol Come From? [Short Guide for Beauty Brands]

Bakuchiol has been all the rage for consumers seeking a natural alternative to retinol for sensitive skin. In this short...

by Dr. Ratan K. ChaudhuriDecember 21, 2023
Read More
Creating a Trustworthy Bakuchiol Product: 3 Red Flags to Avoid

Creating a Trustworthy Bakuchiol Product: 3 Red Flags to Avoid

Bakuchiol is at the top of the list for consumers looking for a natural alternative to retinol, offering all the...

by Dr. Ratan K. ChaudhuriNovember 27, 2023
Read More
The Future of Sytenol® A with Beiersdorf in China: PCT 2023 Recap

The Future of Sytenol® A with Beiersdorf in China: PCT 2023 Recap

Sytenol® A (INCI: Bakuchiol) is making its way around the world – especially as the only source of Bakuchiol now...

by Dr. Ratan K. ChaudhuriAugust 29, 2023
Read More