RK Chaudhuri, T Meyer, S Premi, D Brash, Acetyl Zingerone: An efficacious multifunctional ingredient for continued protection against on-going DNA damage in melanocytes after sun exposure ends, International J Cosmetic Science, 2019 Sep 20. doi: 10.1111/ics.12582. Open access.
Abstract:
Damage to DNA is arguably the most important type of photodamage initiated by sun exposures. Recent research by Yale University has shown that significant levels of cyclobutane pyrimidine dimers (CPDs) in DNA continue to form in melanocytes for several hours in the dark after exposure to ultraviolet radiation (UVR) ends. In collaboration with Yale University scientists, Sytheon has demonstrated utility of a new multifunctional ingredient, 3-(4-hydroxy, 3-methoxybenzyl)-pentane-2,4-dione; INCI Acetyl Zingerone (AZ) to protect melanocytes against CPD formation after UVR exposure ends.
Even when added immediately after irradiation, AZ significantly inhibited on-going formation of CPDs in melanocytes after exposure to UVA. Incubation with AZ before irradiation decreased intracellular levels of UVA-induced ROS formation in keratinocytes. Compared with α-tocopherol, the molecular structure of AZ endows it with significantly better photostability and efficacy to neutralize free radicals (٠OH, ٠OOH), physically quench singlet oxygen (1O2) and scavenge peroxynitrite (ONOO-).
These results designate Synoxyl® AZ as the best-in-class broad-action antioxidant with both quenching and scavenging properties. Synoxyl® AZ has a strong potential to extend photoprotection of traditional sunscreens and daily skin care products over the first few hours after sun exposure ends.
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