Synoxyl® HSS: In-vitro dermal penetration in human skin revealed No skin penetration

Our recent in-vitro dermal penetration study (OECD 428) of Synoxyl® HSS (5% solution in HydraSynol® DOI) in human skin revealed No penetration. Dermal penetration studies are conducted to determine how much of a chemical penetrates the skin, and thereby whether it has the potential to be absorbed into the systemic circulation. Dermal penetration data is also a requirement in establishing Margin of Safety of a substance used topically; non-penetrating substances offer high safety confidence level.

Absorbed dose (corresponds to the quantity of product present in the fluid receptor) and absorbable dose (corresponds to the quantity present in full skin – strip, epidermis & dermis) were found to be 0 and 0.17%. Study result confirms that the systemic exposure to Synoxyl® HSS via topical application contributes in a negligible way to total systemic Synoxyl® HSS exposure.

Our extensive research has demonstrated that Synoxyl® HSS (INCI: Trimethoxybezylidene Pentanedione) is a superb photostabilizer of Avobenzone and other photosensitive compounds, boosts in-vivo SPF by 50% (FDA protocol) for both organic and inorganic sunscreens and protects skin against sun-induced damage by inhibiting upstream ROS cascade.

For more information contact: info@sytheonltd.com

Dr. Ratan K. Chaudhuri is an innovator passionate about helping others, which led to a career in personal care and starting Sytheon in 2006.
Sytheon is actively seeking an exclusive partner to bring its new turnkey product for treating Atopic Dermatitis (eczema) to market.
Hexylresorcinol's benefits as an active ingredient for skin care applications have only begun to be realized.
In a recent study, Pierre Fabre researchers evaluated the effects of Synastol® TC (Terminalia Chebula Fruit Extract) on Senomorphic Targets.
To meet consumer needs, beauty brands must use skincare active ingredients that are scientifically proven to perform.
Sytheon, a global supplier of unique and multifunctional active ingredients, is participating in this year’s Suppliers’ Day in Singapore.
Helping Others with Better Personal Care Ingredients: Sytheon’s Founder Story

Helping Others with Better Personal Care Ingredients: Sytheon’s Founder Story

At an early age, Ratan K. Chaudhuri, PhD, discovered he could leverage scientific research to improve people’s lives. This philosophy...

by Dr. Ratan K. ChaudhuriNovember 30, 2023
Read More
Sytheon Granted 2 New US Patents on Isosorbide Diesters for Treating Atopic Dermatitis, Seeking Exclusive Partner to Bring to Market

Sytheon Granted 2 New US Patents on Isosorbide Diesters for Treating Atopic Dermatitis, Seeking Exclusive Partner to Bring to Market

Sytheon is thrilled to announce that its new turnkey product for treating Atopic Dermatitis (eczema) has further patent protection –...

by Dr. Ratan K. ChaudhuriNovember 3, 2023
Read More
Hexylresorcinol in Skin Care: Short Guide to Synovea® HR

Hexylresorcinol in Skin Care: Short Guide to Synovea® HR

Hexylresorcinol has a 95-year history of use in food and pharmaceuticals, but its benefits as an active ingredient for skin...

by Dr. Ratan K. ChaudhuriOctober 24, 2023
Read More
Synastol® TC (Terminalia Chebula Fruit Extract): A Multifunctional Ingredient for Well-Aging Products

Synastol® TC (Terminalia Chebula Fruit Extract): A Multifunctional Ingredient for Well-Aging Products

In a recent study published in the International Journal of Cosmetic Science, Pierre Fabre researchers evaluated the effects of Synastol®...

by Dr. Ratan K. ChaudhuriSeptember 28, 2023
Read More
Science Meets Beauty: 10 Active Ingredients that Will Enhance Your Skincare Formulation

Science Meets Beauty: 10 Active Ingredients that Will Enhance Your Skincare Formulation

Today’s personal care consumers are vigilant about the ingredients used in their favorite skincare products. They want to know exactly...

by Dr. Ratan K. ChaudhuriSeptember 8, 2023
Read More
Sytheon Takes on Suppliers’ Day in Singapore: Speaking Session & Partner Booth

Sytheon Takes on Suppliers’ Day in Singapore: Speaking Session & Partner Booth

Sytheon, a global supplier of unique and multifunctional active ingredients, is thrilled to announce its participation at this year’s Suppliers’...

by Dr. Ratan K. ChaudhuriSeptember 7, 2023
Read More
document.addEventListener("DOMContentLoaded", function() { var postTitles = document.querySelectorAll('.blfe-post-grid-title'); // Replace '.post-title-class' with the actual class or element selector for your post titles postTitles.forEach(function(title) { title.removeAttribute('rel'); }); });