Synoxyl® AZ
Acetyl Zingerone
Microbiome Friendly, 24/7 Prevention & Repair of Skin Damage
Synoxyl® AZ is a multi-targeted antiaging molecule designed to counteract aging before it happens and to reverse key signs of photo-damaged skin including pigmentation. AZ prevents skin damage and nurtures skin’s own ability to maintain the integrity of the ECM for optimal health and appearance throughout life. AZ thus provides a translational step forward towards development of a truly efficacious molecule to treat or prevent the consequences of intrinsic and extrinsic skin aging.

Synoxyl® AZ at a Glance
Synoxyl® AZ
at a Glance
INCI
Acetyl Zingerone
Use Level
0.5 to 1%
Origin
Organic Synthesis
- Significant reduction in wrinkle severity (>25%) and volume in 4 weeks as compared to placebo
- Significant reduction in pigment intensity (>25%) in 4 weeks as compared to placebo
- Maintains skin microbiome diversity with >20% increase in Staph epidermidis
- Significant reduction (40%) in skin redness induced by UV challenge test
- All-in-one: antioxidant, quencher and selective chelator
- Reduces both immediate and delayed skin damage
- Non-sacrificing stable antioxidant as compared to conventional antioxidants
- Elevates biological skin defenses
Understand how to use Synoxyl® AZ in your formula by requesting the formulation guide.
Key Attributes
Synoxyl® AZ provides a translational step forward in developing a more efficacious molecule to treat or prevent the signs of both natural and environmental skin aging.
Globally approved except China. Work-in-progress for China approval. REACH registered. Patented product.
Globally approved except China.
Work is under way to get China approval.
REACH registered.
Patented product.

Powerful Omni Antioxidant
Synoxyl® AZ has the unique ability to scavenge and quench reactive species, and selectively chelate iron. This makes it the first-in-the-industry omni-antioxidant product.

Strong Skin Defense
Placebo-controlled clinical studies revealed Synoxyl® AZ caused significant improvement in skin defense and the reduction of wrinkles, pigmentation and skin redness in photo-aged skin without using sunscreens.

Photochemically Stable Antioxidant
Unlike many conventional antioxidants, Synoxyl® AZ is a photochemically stable antioxidant. This means it can’t be easily broken down or degraded by exposure to UV light or other forms of radiation.

Effective Skin Rejuvenation
Synoxyl® AZ balances skin microbiome diversity and stimulates skin-friendly Staphylococcus epidermidis by >20%. This keeps your customers’ skin healthy and prevents skin conditions like acne, eczema and psoriasis.

Reliable Skin Protection
Synoxyl® AZ is the first in the industry that prevents cyclobutane pyrimidine dimers (CPDs), reducing immediate and delayed skin damage from UV radiation.
Applications
SKIN DETOX
Anti-Pollution
PHOTO-AGING REPAIR
Before & After Sun
SKIN PROTECTION
Sun Preparation & Daily Skin Care
Publications
J Srivastava. MM Young, VK Yadav, PR Phadatare, TA Meyer, RK Chaudhuri, S Premi
WS Swindell, M Randhawa, G Quijas, K Bojanowski, RK Chaudhuri
S Dhaliwal, I Rybak, A Pourang, W Burney, K Haas, S Sandhu, R Crawford, R Sivamani
Other Ingredients
Trimethoxybenzylidene Pentanedione
Synoxyl® HSS

Solution to make Hawaii-compliant sunscreens
Isosorbide Dicaprylate
Hydra Synol® DOI

A smart lipophilic skin hydrator & barrier builder
Ethyl Linoleate
Synovea® EL

A synergist with multiple skin benefits
Isosorbide Dicaprylate | Bakuchiol | Ethyl Linoleate
Asyntra® D-Stress

Destress your skin