Synoxyl® AZ
Acetyl Zingerone
Microbiome Friendly, 24/7 Prevention & Repair of Skin Damage
Synoxyl® AZ is a multi-targeted antiaging molecule designed to counteract aging before it happens and to reverse key signs of photo-damaged skin including pigmentation. AZ prevents skin damage and nurtures skin’s own ability to maintain the integrity of the ECM for optimal health and appearance throughout life. AZ thus provides a translational step forward towards development of a truly efficacious molecule to treat or prevent the consequences of intrinsic and extrinsic skin aging.

Synoxyl® AZ at a Glance
Synoxyl® AZ
at a Glance
INCI
Acetyl Zingerone
Use Level
0.5 to 1%
Origin
Organic Synthesis
- Significant reduction in wrinkle severity (>25%) and volume in 4 weeks as compared to placebo
- Significant reduction in pigment intensity (>25%) in 4 weeks as compared to placebo
- Maintains skin microbiome diversity with >20% increase in Staph epidermidis
- Significant reduction (40%) in skin redness induced by UV challenge test
- All-in-one: antioxidant, quencher and selective chelator
- Reduces both immediate and delayed skin damage
- Non-sacrificing stable antioxidant as compared to conventional antioxidants
- Elevates biological skin defenses
Understand how to use Synoxyl® AZ in your formula by requesting the formulation guide.
Key Attributes
Synoxyl® AZ provides a translational step forward in developing a more efficacious molecule to treat or prevent the signs of both natural and environmental skin aging.
Globally approved except China. Work is under way to get China approval. REACH registered. Patented product.
Globally approved except China.
Work is under way to get China approval.
REACH registered.
Patented product.

Powerful Omni Antioxidant
Synoxyl® AZ has the unique ability to scavenge and quench reactive species, and selectively chelate iron. This makes it the first-in-the-industry omni-antioxidant product.

Strong Skin Defense
Placebo-controlled clinical studies revealed Synoxyl® AZ caused significant improvement in skin defense and the reduction of wrinkles, pigmentation and skin redness in photo-aged skin without using sunscreens.

Photochemically Stable Antioxidant
Unlike many conventional antioxidants, Synoxyl® AZ is a photochemically stable antioxidant. This means it can’t be easily broken down or degraded by exposure to UV light or other forms of radiation.

Effective Skin Rejuvenation
Synoxyl® AZ balances skin microbiome diversity and stimulates skin-friendly Staphylococcus epidermidis by >20%. This keeps your customers’ skin healthy and prevents skin conditions like acne, eczema and psoriasis.

Reliable Skin Protection
Synoxyl® AZ is the first in the industry that prevents cyclobutane pyrimidine dimers (CPDs), reducing immediate and delayed skin damage from UV radiation.
Applications
SKIN DETOX
Anti-Pollution
PHOTO-AGING REPAIR
Before & After Sun
SKIN PROTECTION
Sun Preparation & Daily Skin Care
Publications
J Srivastava. MM Young, VK Yadav, PR Phadatare, TA Meyer, RK Chaudhuri, S Premi
WS Swindell, M Randhawa, G Quijas, K Bojanowski, RK Chaudhuri
S Dhaliwal, I Rybak, A Pourang, W Burney, K Haas, S Sandhu, R Crawford, R Sivamani
Other Ingredients
Trimethoxybenzylidene Pentanedione
Synoxyl® HSS

Solution to make Hawaii-compliant sunscreens
Isosorbide Dicaprylate
Hydra Synol® DOI

A smart lipophilic skin hydrator & barrier builder
Ethyl Linoleate
Synovea® EL

A synergist with multiple skin benefits
Isosorbide Dicaprylate | Bakuchiol | Ethyl Linoleate
Asyntra® D-Stress

Destress your skin