Synoxyl® AZ
Acetyl Zingerone

Microbiome Friendly, 24/7 Prevention & Repair of Skin Damage

Synoxyl® AZ is a multi-targeted antiaging molecule designed to counteract aging before it happens and to reverse key signs of photo-damaged skin including pigmentation. AZ prevents skin damage and nurtures skin’s own ability to maintain the integrity of the ECM for optimal health and appearance throughout life. AZ thus provides a translational step forward towards development of a truly efficacious molecule to treat or prevent the consequences of intrinsic and extrinsic skin aging.

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Synoxyl® AZ at a Glance

Synoxyl® AZ

 at a Glance


Acetyl Zingerone

Use Level

0.5 to 1%


Organic Synthesis

Key Results from Clinical Studies
  • Significant reduction in wrinkle severity (>25%) and volume in 4 weeks as compared to placebo
  • Significant reduction in pigment intensity (>25%) in 4 weeks as compared to placebo
  • Maintains skin microbiome diversity with >20% increase in Staph epidermidis
  • Significant reduction (40%) in skin redness induced by UV challenge test
  • All-in-one: antioxidant, quencher and selective chelator
  • Reduces both immediate and delayed skin damage
  • Non-sacrificing stable antioxidant as compared to conventional antioxidants
  • Elevates biological skin defenses
Formulation Guide

Understand how to use Synoxyl® AZ in your formula by requesting the formulation guide.

Key Attributes

Synoxyl® AZ provides a translational step forward in developing a more efficacious molecule to treat or prevent the signs of both natural and environmental skin aging.
Globally approved except China. Work-in-progress for China approval. REACH registered. Patented product.





Before & After Sun


Sun Preparation & Daily Skin Care


Antioxidants, 12(2), 278, 2023

J Srivastava. MM Young, VK Yadav, PR Phadatare, TA Meyer, RK Chaudhuri, S Premi

J Cosmetic Dermatology, 20(1):166-173, 2021

S Dhaliwal, I Rybak, A Pourang, W Burney, K Haas, S Sandhu, R Crawford, R Sivamani

Other Ingredients

Trimethoxybenzylidene Pentanedione

Synoxyl® HSS

Synoxyl HSS

Solution to make Hawaii-compliant sunscreens

Isosorbide Dicaprylate

Hydra Synol® DOI

A smart lipophilic skin hydrator & barrier builder

Ethyl Linoleate

Synovea® EL

A synergist with multiple skin benefits

Isosorbide Dicaprylate | Bakuchiol | Ethyl Linoleate

Asyntra® D-Stress

Destress your skin