Clinical Study: Synovea® HR (Hexylresorcinol) vs. Hydroquinone for Skin Pigment Appearance

In a recent article published in the Archives of Dermatological Research, Synovea® HR (INCI: Hexylresorcinol) and hydroquinone are the focus of a double-blind study to determine their effectiveness for remedying dyspigmentation.

Dyspigmentation is an abnormality in the pigmentation of the skin that’s a common concern in dermatology. In the United States, a popular topical medication for dyspigmentation is hydroquinone, a synthetic compound that reduces melanin production to help lighten dark spots and other forms of hyperpigmentation.

The problem with hydroquinone is its potential safety issues:

  • Cytotoxicity to melanocytes
  • Systemic absorption
  • Metabolism in distant organs
  • The production of potentially carcinogenic metabolites
  • Skin rashes, facial swelling and ochronosis (discoloration of the skin)

Because of these concerns, dermatologists/researchers considered Synovea® HR a possible alternative due to its skin-lightening and even toning properties. The dermatologists/researchers performed a double-blind randomized split-body study to compare how topical Synovea® HR and hydroquinone affected the skin tone and pigmentation on the face and hands.

The study included 32 healthy female participants between 35-65 years old who received either topical 1% Synovea® HR or topical 2% hydroquinone. The topical preparation was applied to either the left or right side of the face and the corresponding hand over a 12-week period. The results found that pigmentation was significantly reduced at 4 and 12 weeks with no difference between groups and no adverse effects.

In conclusion, 1% of Synovea® HR in a topical application is a well-tolerated ingredient that’s equal to 2% hydroquinone in reducing facial and hand dyspigmentation.

To access the article, click here.

Sytheon recently published breakthrough research on acetyl zingerone and tetrahexyldecyl ascorbate’s effectiveness on skin photoaging.
Synastol® TC is a natural, safe ingredient that can now be used as a nutritional supplement, providing holistic benefits for customers.
Acetyl Zingerone is a perfect active for your next sun care product that protects the skin before, during and after sun exposure. Here’s how.
Hexylresorcinol does not pose the same dangers as resorcinol. Keep reading to understand the differences between these ingredients.
Here are the top five skin care ingredient trends that forward-thinking brands should capitalize on in 2024.
Dr. Ratan K. Chaudhuri is an innovator passionate about helping others, which led to a career in personal care and starting Sytheon in 2006.
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