Synovea® HR (INCI: Hexylresorcinol) is the new gold standard in skin lightening. It provides the best ratio between safety and performance as a skin lightener, dark spot corrector and even toner.
Synovea® HR has been clinically proven to brighten the skin’s complexion, provide effective melanin inhibitory activity, and show a significant improvement in skin clarity, complexion, and hydration. It has been tested against Hydroquinone and found to be 2X more effective and much safer to use.
Synovea® HR can be formulated into a wide range of skin care and color cosmetic applications following the formulation tips & FAQs listed below.
Formulation Tips
- Synovea® HR is soluble in a wide range of emollients, humectants and surfactants.
25%
Hydra Synol® DOI, Synovea® EL, PEG-8, Caprylic/Capric Triglyceride, C12-15 Alkyl Benzoate and Isopropyl Palmitate
20%
Butylene Glycol, Propanediol, Ethoxydiglycol, Polysorbate 20
- In a side phase, weight Synovea® HR and the proper amount of solubilizer and mix until all solids are dissolved. Slight heating may be required, but do not heat above 45-50°C.
- Add side phase of solubilizer and Synovea® HR to the main batch when it’s cooling down and is below 50°C.
- Higher shear may be required to fully disperse the Synovea® HR solution in the main batch. In this case, add the solubilizer and Synovea® HR phase to the main batch on the homogenizer.
FAQs About Synovea® HR
0.5-1%.
Lotion containing 1% Synovea® HR was clinically proven to reduce pigmentation without affecting surrounding areas.
It is not recommended to go above the 1% use level of Synovea® HR. It can be too irritating at higher amounts.
Yes! Synovea® HR is also REACH compliant and globally approved.
Synovea® HR is an amphiphilic molecule meaning it is easy to solubilize in polar and non-polar solvents.
- Oil-soluble ingredients: hydrophobic emollient esters and other high polarity esters, Hydra Synol® DOI, Caprylic/Capric Triglycerides, and Synovea® EL.
- Water-soluble ingredients: Ethoxydiglycol, Butylene Glycol, non-ionic solubilizers, glycerol, and a wide range of glycols.
Because Synovea® HR is a phenolic compound, it is incompatible with sodium hydroxide, potassium hydroxide and aluminum hydroxide. It is also incompatible with ethanol.
Synovea® HR as a raw material is white to off-white in color. When dissolved in a solubilizer, the solution will be a pale yellow, but it should not color the formula.
No, Synovea® HR is not heat stable and needs to be added to the formula below 50C.
Synovea® HR is a phenolic compound and needs to be formulated into products within the acidic pH range (below 6.5). Formulators should check the pH range acceptable for all other ingredients as well.
Iron or copper ions can affect the color of a product with Synovea® HR. These metals ions can be present in water and can also be produced by UV radiation.
To avoid interaction with Synovea® HR and metal ions, the following measures can be taken:
- Add a chelating agent at 0.1-0.3% (Examples: EDTA, EDDS, Sodium Phytate)
- Use airless and/or opaque packaging
Yes, Synovea® HR is photostable. However, opaque packaging is recommended for the final product.
Synovea® HR can be formulated into the following:
Milks, Body Butters, Serums, Emulsions, Moisturizers, Lotions, Masks, Sensitive Skin Products, Gels & Jellies, Creams, Make-up, Oils, Blush, Body care, Face care, BB Creams, Skin Care, CC Creams, Balms
Synovea® HR can be formulated into the following:
Foundations, CC Creams, BB Creams, Make-Up, Blush
Synovea® HR cannot be formulated into the following:
Eye Products, Toners, Hot Pour Products
Synovea® HR is a hygroscopic material and can form agglomerates if not stored properly. Synovea® HR should be stored in the original sealed container at +10 to +30°C. Avoid exposure to light, heat, and moisture. It remains stable for over three years.
No, Synovea® HR does not have a smell.