Publications

At Sytheon, we rigorously test all of our ingredients – leaving no questions unanswered. Read our research in various publications to discover how our ingredients can meet the needs of your customers.

Groundbreaking Research on High-Performing Actives

Explore our research that supports each active we offer.

Synastol® TC (Terminalia Chebula Fruit Extract)

Double-blind randomized placebo-controlled supplementation of a standardized Terminalia chebula fruit extract alters the gut microbiome, phageome, and increases short chain fatty acids in High-BMI, borderline diabetic females

Journal of Functional Foods, Volume 119, 2024

M Min, M Chakkalakal, A Pan, D Nadora, N Gahoonia, S Thacker, RK Chaudhuri, W Burney, RK Sivamani

Synoxyl® AZ (Acetyl Zingerone)

Prospective randomized double-blind comparative study of topical acetyl zingerone with tetrahexyldecyl ascorbate versus tetrahexyldecyl ascorbate alone on facial photoaging

Cosmet Dermatol. 2024; 00: 1-11.

N Afzal, N Nguyen, M Min, C Egli, B Ed, S Afzal, RK Chaudhuri, WA Burney, RK Sivamani

ActSES® (Isosorbide Di–(Linoleate/oleate) & Isosorbide Di-Caprylate

Prospective Randomized Double-Blind Vehicle-Controlled Study of Topical Coconut and Sunflower Seed Oil-Derived Isosorbide Diesters on Atopic Dermatitis

DERMATITIS, Vol 35, 2024

D Nadora, W Burney, RK Chaudhuri, A Galati, M Min, S Fong, K Lo, CJ Chambers, RK Sivamani

Synastol® TC (Terminalia Chebula Fruit Extract)

Reduction of senescence-associated secretory phenotype and exosome-shuttled miRNAs by Haritaki fruit extract in senescent dermal fibroblasts

Int J Cosmet Sci., doi: 10.1111/ics.12858, 2023

P Bogdanowicz, N Roullet, P Bensadoun, S Bessou-Touya, JM Lemaitre, H Duplan

Synoxyl® AZ (Acetyl Zingerone)

Acetyl Zingerone: A Photostable Multifunctional Skincare Ingredient That Combats Features of Intrinsic and Extrinsic Skin Aging

Antioxidants, 12(6):1168, 2023

TA Meyer, WR Swindell, RK Chaudhuri

Asyntra® D-Stress (Isosorbide Dicaprylate & Bakuchiol & Ethyl Linoleate), Synovea EL® (Ethyl Linoleate), Sytenol® A (Bakuchiol)

Bakuchiol and Ethyl (Linoleate/Oleate) Synergistically Modulate Endocannabinoid Tone in Keratinocytes and Repress Inflammatory Pathway mRNAs

JID Innovations, 3(3): 100178, 2023

WR Swindell, K Bojanowski, P Singh, M Randhawa, RK Chaudhuri

Synoxyl® AZ (Acetyl Zingerone)

The Role of Acetyl Zingerone and Its Derivatives in Inhibiting UV-Induced, Incident, and Delayed Cyclobutane Pyrimidine Dimers

Antioxidants, 12(2), 278, 2023

J Srivastava. MM Young, VK Yadav, PR Phadatare, TA Meyer, RK Chaudhuri, S Premi

Synastol® TC (Terminalia Chebula Fruit Extract)

Randomized Double-Blind Placebo-Controlled Supplementation with Standardized Terminalia chebula Fruit Extracts Reduces Facial Sebum Excretion, Erythema, and Wrinkle Severity

J. Clinical Medicine, 12(4), 1591, 2023

M Chakkalakal, A Pan, D Nadora, N Gahoonia, RK Chaudhuri, W Burney, S Thacker, A Shakhbazova, C Subramanyam, CJ Chambers, RK Sivamani

Sytenol® A (Bakuchiol)

Finding the right Bakuchiol: Choose wisely

J Cosmetic Dermatology, 2023

N Afzal and RK Sivamani

ActSES® (Isosorbide Di–(Linoleate/oleate) & Isosorbide Di-Caprylate, Hydra Synol® DOI (Isosorbide Dicaprylate)

Isosorbide Fatty Acid Diesters Have Synergistic Anti-Inflammatory Effects in Cytokine-Induced Tissue Culture Models of Atopic Dermatitis

International J Molecular Science, 23, 14307, 2022

WR Swindell, K Bojanowski, RK Chaudhuri

Synovea® HR (Hexylresorcinol)

Prospective, randomized, double-blind clinical study of split-body comparison of topical hydroquinone and hexylresorcinol for skin pigment appearance

Archive Dermatological Research, 315:1207-1214, 2022

H Wu, TA Gabriel, WA Burney, CJ Chambers, A Pan, RK Sivamani

Sytenol® A (Bakuchiol)

Multidirectional activity of bakuchiol against cellular mechanisms of facial ageing – Experimental evidence for a holistic treatment approach

International J Cosmetic Science, 44(3): 377-393, 2022

A Bluemeke, AP Ring, J Immeyer et al.

Sytenol® A (Bakuchiol)

Applications of Bakuchiol in dermatology: Systematic review of the literature

J Cosmetic Dermatology, 21(12):6636-6643, 2022

C Puyana, N Chandan, MJ Tsoukas

ActSES® (Isosorbide Di–(Linoleate/oleate) & Isosorbide Di-Caprylate

Isosorbide Di-(Linoleate/Oleate) Stimulates Prodifferentiation Gene Expression to Restore the Epidermal Barrier and Improve Skin Hydration

J Investigative Dermatology,141(6):1416-1427.e12., 2021

K Bojanowski, WR Swindell, S Cantor, RK Chaudhuri

Synovea EL® (Ethyl Linoleate)

Isosorbide Di-(Linoleate/Oleate) Stimulates Prodifferentiation Gene Expression to Restore the Epidermal Barrier and Improve Skin Hydration

Journal of Investigative Dermatology , 141(6), 1416-1427, 2021

K Bojanowski, WR Swindell, S Cantor, RK Chaudhuri

Synoxyl® AZ (Acetyl Zingerone)

Tetrahexyldecyl Ascorbate (THDC) Degrades Rapidly under Oxidative Stress but Can Be Stabilized by Acetyl Zingerone to Enhance Collagen Production and Antioxidant Effects

International J Molecular Sciences, 22:8756, 2021

WS Swindell, M Randhawa, G Quijas, K Bojanowski, RK Chaudhuri

Sytenol® A (Bakuchiol)

Crosstalk between HIF-1α and SIRT-1 is bolstered by the natural ingredient bakuchiol but not retinol

J American Academy of Dermatology, 27702, 2021

H Gunt, M Randhawa, K Bojanowski, and RK Chaudhuri

Synoxyl® AZ (Acetyl Zingerone)

Randomized Double-Blind Vehicle Controlled Study of the Effects of Topical Acetyl Zingerone on Photoaging

J Cosmetic Dermatology, 20(1):166-173, 2021

S Dhaliwal, I Rybak, A Pourang, W Burney, K Haas, S Sandhu, R Crawford, R Sivamani

VitaSynol® C (Tetrahexyldecyl Ascorbate)

Tetrahexyldecyl Ascorbate (THDC) Degrades Rapidly under Oxidative Stress but Can Be Stabilized by Acetyl Zingerone to Enhance Collagen Production and Antioxidant Effects

International J Molecular Sciences, 22:8756, 2021

WS Swindell, M Randhawa, G Quijas, K Bojanowski, RK Chaudhuri

Synastol® TC (Terminalia Chebula Fruit Extract)

Standardized Terminalia chebula Fruit Extract: A Natural Ingredient That Provides Long-Lasting Antioxidant Protection and Reverses Visible Signs of Pollution-Induced Skin Damage

Original Research, 17 September 2021

Randhawa M, Meyer T, Sachdev M, Chaudhuri RK