Publications

At Sytheon, we rigorously test all of our ingredients – leaving no questions left unanswered. Read our research in various publications to discover how our ingredients can meet the needs of your customers.

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Groundbreaking Research on High-Performing Actives

Explore our research that supports each active we offer.
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Bakuchiol and Ethyl (Linoleate/Oleate) Synergistically Modulate Endocannabinoid Tone in Keratinocytes and Repress Inflammatory Pathway mRNAs

JID Innovations, 3(3): 100178, 2023

WR Swindell, K Bojanowski, P Singh, M Randhawa, RK Chaudhuri

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Bakuchiol and Ethyl

Isosorbide Di-(Linoleate/Oleate) Stimulates Prodifferentiation Gene Expression to Restore the Epidermal Barrier and Improve Skin Hydration

Journal of Investigative Dermatology , 141(6), 1416-1427, 2021

K Bojanowski, WR Swindell, S Cantor, RK Chaudhuri

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Isosorbide Di-(Linoleate/Oleate)

Isosorbide Fatty Acid Diesters Have Synergistic Anti-Inflammatory Effects in Cytokine-Induced Tissue Culture Models of Atopic Dermatitis

International J Molecular Science, 23, 14307, 2022

WR Swindell, K Bojanowski, RK Chaudhuri

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Isosorbide Fatty Acid Diesters

Prospective, randomized, double-blind clinical study of split-body comparison of topical hydroquinone and hexylresorcinol for skin pigment appearance

Archive Dermatological Research, 2022

H Wu, TA Gabriel, WA Burney, CJ Chambers, A Pan, RK Sivamani

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Prospective, randomized, double-blind clinical study of split-body comparison of topical hydroquinone and hexylresorcinol
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When Acne Attacks, Hexylresorcinol and Ethyl Linoleate Fight Back: Strategy (part I)

Cosmetics & Toiletries, Article # 21836613, 2016

RK Chaudhuri, Z Lascu, F Marchio

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When Acne Attacks, Hexylresorcinol and Ethyl Linoleate Fight Back: Experimental (part II)

Cosmetics & Toiletries, Article # 21836614, 2016

RK Chaudhuri, Z Lascu and F Marchio

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When Acne Attacks Part 2

The Role of Acetyl Zingerone and Its Derivatives in Inhibiting UV-Induced, Incident, and Delayed Cyclobutane Pyrimidine Dimers

Antioxidants, 12, 278, 2023

J Srivastava. MM Young, VK Yadav, PR Phadatare, TA Meyer, RK Chaudhuri, S Premi

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The Role of Acetyl Zingerone

Randomized Double-Blind Placebo-Controlled Supplementation with Standardized Terminalia chebula Fruit Extracts Reduces Facial Sebum Excretion, Erythema, and Wrinkle Severity

J. Clinical Medicine, 12, 1591, 2023

M Chakkalakal, A Pan, D Nadora, N Gahoonia, RK Chaudhuri, W Burney, S Thacker, A Shakhbazova, C Subramanyam, CJ Chambers, RK Sivamani

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Randomized Double-Blind Placebo-Controlled Supplementation with Standardized Terminalia chebula Fruit Extracts

Finding the right Bakuchiol: Choose wisely

J Cosmetic Dermatology, 2023

N Afzal and RK Sivamani

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Standardized Terminalia chebula Fruit Extract: A Natural Ingredient That Provides Long-Lasting Antioxidant Protection and Reverses Visible Signs of Pollution-Induced Skin Damage

Clinical, Cosmetic, & Investigational Dermatology, 14:1257-1269, 2021

M Randhawa , T Meyer , M Sachdev , RK Chaudhuri

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A Standardized Terminalia chebula Fruit Extract Alters the Expression of Genes Associated with Skin Artichecture and Barrier Formation

European J Dermatology, 2020

WS Swindell, K Bojanowski, RK Chaudhuri

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Hexylresorcinol: Providing Skin Benefits by Modulating Multiple Molecular Targets

In Cosmeceuticals and Active Cosmetics, 3rd Edition, Chapter 7, 2015

RK Chaudhuri; Editors: RK Sivamani, J Jagdeo, P Elsner & HI Maibach, Francis & Taylor, Boca Raton

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Tetrahexyldecyl Ascorbate (THDC) Degrades Rapidly under Oxidative Stress but Can Be Stabilized by Acetyl Zingerone to Enhance Collagen Production and Antioxidant Effects

International J Molecular Sciences, 22:8756, 2021

WS Swindell, M Randhawa, G Quijas, K Bojanowski, RK Chaudhuri

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Multidirectional activity of bakuchiol against cellular mechanisms of facial ageing – Experimental evidence for a holistic treatment approach

International J Cosmetic Science, 44(3): 377-393, 2022

A Bluemeke, AP Ring, J Immeyer et al.

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Crosstalk between HIF-1α and SIRT-1 is bolstered by the natural ingredient bakuchiol but not retinol

J American Academy of Dermatology, 27702, 2021

H Gunt, M Randhawa, K Bojanowski, and RK Chaudhuri

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Clinical evaluation of a nature-based bakuchiol anti-aging moisturizer for sensitive Skin

J Drugs in Dermatology, 19(12):1181-1183, 2020

ZD Draelos, H Gunt, J Zeichner, S Levy

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Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoaging

British J Dermatology, 180, 289–296, 2019

S. Dhaliwal, I. Rybak, S.R. Ellis, M. Notay, M. Trivedi, W. Burney, A.R. Vaughn, M. Nguyen, P. Reiter, S. Bosanac, H. Yan, N. Foolad, R.K. Sivamani

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4-Hexyl-1,3-phenylenediol, a nuclear factor ĸB inhibitor, improves photodamaged skin and clinical signs of ageing in a double-blinded controlled trial

British J Dermatology, 173:218-226, 2015

S Kaur, M Kizoulis, J Fantasia, T Oddos, N Bigot, P Galera , S Tucker-Samaras, J J Leyden, M D Southall

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4‐Hexyl‐1,3‐phenylenediol, a nuclear factor‐κB inhibitor

Randomized Double-Blind Vehicle Controlled Study of the Effects of Topical Acetyl Zingerone on Photoaging

J Cosmetic Dermatology, 20(1):166-173, 2021

S Dhaliwal, I Rybak, A Pourang, W Burney, K Haas, S Sandhu, R Crawford, R Sivamani

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Bakuchiol may be another natural solution to reverse the course of nature

British J Dermatology, 180:253-254, 2019

ML Levy

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Inspired By Nature.

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