Synactin AC® (Caprylic/Capric Triglycerides & Ethyl Linoleate & Hexylresorcinol), Synovea EL® (Ethyl Linoleate), Synovea® HR (Hexylresorcinol)

When Acne Attacks, Hexylresorcinol and Ethyl Linoleate Fight Back

Cosmetics & Toiletries, Vol. 131, No. 7, 2016

RK Chaudhuri, Z Lascu, F Marchio

Synastol® TC (Terminalia Chebula Fruit Extract)

Reduction of senescence-associated secretory phenotype and exosome-shuttled miRNAs by Haritaki fruit extract in senescent dermal fibroblasts

Int J Cosmet Sci. 2023 Mar 20. doi: 10.1111/ics.12858

Bogdanowicz P, Roullet N, Bensadoun P, Bessou-Touya S, Lemaitre JM, Duplan H

Synoxyl® AZ (Acetyl Zingerone)

Acetyl Zingerone: A Photostable Multifunctional Skincare Ingredient That Combats Features of Intrinsic and Extrinsic Skin Aging

Antioxidants. 2023; 12(6):1168

Meyer TA, Swindell WR, Chaudhuri RK

Asyntra® D-Stress (Isosorbide Dicaprylate & Bakuchiol & Ethyl Linoleate), Synovea EL® (Ethyl Linoleate), Sytenol® A (Bakuchiol)

Bakuchiol and Ethyl (Linoleate/Oleate) Synergistically Modulate Endocannabinoid Tone in Keratinocytes and Repress Inflammatory Pathway mRNAs

JID Innovations, 3(3): 100178, 2023

WR Swindell, K Bojanowski, P Singh, M Randhawa, RK Chaudhuri

Synovea EL® (Ethyl Linoleate)

Isosorbide Di-(Linoleate/Oleate) Stimulates Prodifferentiation Gene Expression to Restore the Epidermal Barrier and Improve Skin Hydration

Journal of Investigative Dermatology , 141(6), 1416-1427, 2021

K Bojanowski, WR Swindell, S Cantor, RK Chaudhuri

Hydra Synol® DOI (Isosorbide Dicaprylate)

Isosorbide Fatty Acid Diesters Have Synergistic Anti-Inflammatory Effects in Cytokine-Induced Tissue Culture Models of Atopic Dermatitis

International J Molecular Science, 23, 14307, 2022

WR Swindell, K Bojanowski, RK Chaudhuri

Synovea® HR (Hexylresorcinol)

Prospective, randomized, double-blind clinical study of split-body comparison of topical hydroquinone and hexylresorcinol for skin pigment appearance

Archive Dermatological Research, 2022

H Wu, TA Gabriel, WA Burney, CJ Chambers, A Pan, RK Sivamani

Synoxyl® AZ (Acetyl Zingerone)

The Role of Acetyl Zingerone and Its Derivatives in Inhibiting UV-Induced, Incident, and Delayed Cyclobutane Pyrimidine Dimers

Antioxidants, 12, 278, 2023

J Srivastava. MM Young, VK Yadav, PR Phadatare, TA Meyer, RK Chaudhuri, S Premi

Synastol® TC (Terminalia Chebula Fruit Extract)

Randomized Double-Blind Placebo-Controlled Supplementation with Standardized Terminalia chebula Fruit Extracts Reduces Facial Sebum Excretion, Erythema, and Wrinkle Severity

J. Clinical Medicine, 12, 1591, 2023

M Chakkalakal, A Pan, D Nadora, N Gahoonia, RK Chaudhuri, W Burney, S Thacker, A Shakhbazova, C Subramanyam, CJ Chambers, RK Sivamani

Sytenol® A (Bakuchiol)

Finding the right Bakuchiol: Choose wisely

J Cosmetic Dermatology, 2023

N Afzal and RK Sivamani

Synastol® TC (Terminalia Chebula Fruit Extract)

Standardized Terminalia chebula Fruit Extract: A Natural Ingredient That Provides Long-Lasting Antioxidant Protection and Reverses Visible Signs of Pollution-Induced Skin Damage

Clinical, Cosmetic, & Investigational Dermatology, 14:1257-1269, 2021

M Randhawa , T Meyer , M Sachdev , RK Chaudhuri

Synastol® TC (Terminalia Chebula Fruit Extract)

A Standardized Terminalia chebula Fruit Extract Alters the Expression of Genes Associated with Skin Artichecture and Barrier Formation

European J Dermatology, 2020

WS Swindell, K Bojanowski, RK Chaudhuri

Synovea® HR (Hexylresorcinol)

Hexylresorcinol: Providing Skin Benefits by Modulating Multiple Molecular Targets

In Cosmeceuticals and Active Cosmetics, 3rd Edition, Chapter 7, 2015

RK Chaudhuri; Editors: RK Sivamani, J Jagdeo, P Elsner & HI Maibach, Francis & Taylor, Boca Raton

Synoxyl® AZ (Acetyl Zingerone)

Tetrahexyldecyl Ascorbate (THDC) Degrades Rapidly under Oxidative Stress but Can Be Stabilized by Acetyl Zingerone to Enhance Collagen Production and Antioxidant Effects

International J Molecular Sciences, 22:8756, 2021

WS Swindell, M Randhawa, G Quijas, K Bojanowski, RK Chaudhuri

Sytenol® A (Bakuchiol)

Multidirectional activity of bakuchiol against cellular mechanisms of facial ageing – Experimental evidence for a holistic treatment approach

International J Cosmetic Science, 44(3): 377-393, 2022

A Bluemeke, AP Ring, J Immeyer et al.

Sytenol® A (Bakuchiol)

Crosstalk between HIF-1α and SIRT-1 is bolstered by the natural ingredient bakuchiol but not retinol

J American Academy of Dermatology, 27702, 2021

H Gunt, M Randhawa, K Bojanowski, and RK Chaudhuri

Sytenol® A (Bakuchiol)

Clinical evaluation of a nature-based bakuchiol anti-aging moisturizer for sensitive Skin

J Drugs in Dermatology, 19(12):1181-1183, 2020

ZD Draelos, H Gunt, J Zeichner, S Levy

Sytenol® A (Bakuchiol)

Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoaging

British J Dermatology, 180, 289–296, 2019

S. Dhaliwal, I. Rybak, S.R. Ellis, M. Notay, M. Trivedi, W. Burney, A.R. Vaughn, M. Nguyen, P. Reiter, S. Bosanac, H. Yan, N. Foolad, R.K. Sivamani

Synovea® HR (Hexylresorcinol)

4-Hexyl-1,3-phenylenediol, a nuclear factor ĸB inhibitor, improves photodamaged skin and clinical signs of ageing in a double-blinded controlled trial

British J Dermatology, 173:218-226, 2015

S Kaur, M Kizoulis, J Fantasia, T Oddos, N Bigot, P Galera , S Tucker-Samaras, J J Leyden, M D Southall

Synoxyl® AZ (Acetyl Zingerone)

Randomized Double-Blind Vehicle Controlled Study of the Effects of Topical Acetyl Zingerone on Photoaging

J Cosmetic Dermatology, 20(1):166-173, 2021

Publications

Groundbreaking Research on High-Performing Actives

Synactin AC® (Caprylic/Capric Triglycerides & Ethyl Linoleate & Hexylresorcinol), Synovea EL® (Ethyl Linoleate), Synovea® HR (Hexylresorcinol)

RK Chaudhuri, Z Lascu, F Marchio

Bogdanowicz P, Roullet N, Bensadoun P, Bessou-Touya S, Lemaitre JM, Duplan H

Meyer TA, Swindell WR, Chaudhuri RK

Asyntra® D-Stress (Isosorbide Dicaprylate & Bakuchiol & Ethyl Linoleate), Synovea EL® (Ethyl Linoleate), Sytenol® A (Bakuchiol)

WR Swindell, K Bojanowski, P Singh, M Randhawa, RK Chaudhuri

K Bojanowski, WR Swindell, S Cantor, RK Chaudhuri

WR Swindell, K Bojanowski, RK Chaudhuri

H Wu, TA Gabriel, WA Burney, CJ Chambers, A Pan, RK Sivamani

J Srivastava. MM Young, VK Yadav, PR Phadatare, TA Meyer, RK Chaudhuri, S Premi

M Chakkalakal, A Pan, D Nadora, N Gahoonia, RK Chaudhuri, W Burney, S Thacker, A Shakhbazova, C Subramanyam, CJ Chambers, RK Sivamani

N Afzal and RK Sivamani

M Randhawa , T Meyer , M Sachdev , RK Chaudhuri

WS Swindell, K Bojanowski, RK Chaudhuri

RK Chaudhuri; Editors: RK Sivamani, J Jagdeo, P Elsner & HI Maibach, Francis & Taylor, Boca Raton

WS Swindell, M Randhawa, G Quijas, K Bojanowski, RK Chaudhuri

A Bluemeke, AP Ring, J Immeyer et al.

H Gunt, M Randhawa, K Bojanowski, and RK Chaudhuri

ZD Draelos, H Gunt, J Zeichner, S Levy

S. Dhaliwal, I. Rybak, S.R. Ellis, M. Notay, M. Trivedi, W. Burney, A.R. Vaughn, M. Nguyen, P. Reiter, S. Bosanac, H. Yan, N. Foolad, R.K. Sivamani

S Kaur, M Kizoulis, J Fantasia, T Oddos, N Bigot, P Galera , S Tucker-Samaras, J J Leyden, M D Southall

S Dhaliwal, I Rybak, A Pourang, W Burney, K Haas, S Sandhu, R Crawford, R Sivamani

Inspired By Nature.

Built For Performance.

Actives

Our Products