Synovea® HR

Synovea® HR

The Gold Standard in Skin Brightening & Even Toning

Synovea® HR is the new gold standard in skin lightening. It provides the best ratio between safety and performances as a skin lightener and even toner. It works by modulating the melanogenesis pathway, is a stimulator of glutathione and an inhibitor of NFkB. Hexylresorcinol is clinically proven to be four-times more effective than Hydroquinone. Multiple clinical studies with Synovea® HR demonstrated its strong performance in skin brightening and hyper-pigmentation control for all phototypes, with anti-aging benefits.

Globally Approved. REACH registered. Patented product

Product Summary

  • Hexylresorcinol
Clinical studies
  • 2 to 4-times more effective than Hydroquinone
  • Significant improvement in:
    • Skin lightening & even toning
    • Skin complexion
    • Significant reduction (20%) in skin age spots in 4 weeks
  • Excellent safety profile
  • Photochemically stable skin lightener
  • Amphiphilic-Easy to solubilize in polar and nonpolar solvents
Use Level
  • 0.5 to 1%
  • Organic synthesis


Skin Lightening and Even Toner

Hyperpigmentation or Dark Spot Correction



Synovea® HR

INCI: Hexylresorcinol

  • RK Chaudhuri, Z Lascu & F Marchio, When acne attacks, hexylresorcinol and ethyl linoleate fight back on multiple fronts, Cosm & Toil, 131(7):54-67, 2016
  • RK Chaudhuri, Hexylresorcinol: Providing skin benefits by modulating multiple molecular targets, In Cosmeceuticals and Active Cosmetics, 3r Edition, Eds., RK Sivamani, J Jagdeo, P Elsner & HI Maibach, Francis & Taylor, Boca Raton, Chapter 7, 73-83, 2015
  • S. Kaur et al., 4-Hexyl-1,3-phenylenediol, a nuclear factor ĸB inhibitor, improves photodamaged skin and clinical signs of ageing in a double-blinded controlled trial, British J Dermatology, 173:218-226, 2015
  • YK Won et al, Clinical efficacy and safety of 4-hexyl-1,3-phenylendiol (Hexylresorcinol) for improving skin hyperpigmentation, Arch Dermatol Res, 306(5):455-465, 2014
  • RK Chaudhuri, Effective skin lightening with skin protective properties, Personal Care, 39-44, 2010

Other Ingredients

Sytenol® A, The True Bakuchiol is Now

APPROVED for use in China