New Application: Synastol® TC (Terminalia Chebula Fruit Extract) Now Available as a Nutritional Supplement

Get Your Gut in the Game of Skin Beauty – The Science Behind Standardized Terminalia Chebula Fruit Extract for Delivering Beauty from the Inside-Out

Sytheon is excited to share that Synastol® TC is now available as a nutritional supplement – the first standardized Terminalia Chebula Fruit Extract for this application in the industry.

Terminalia chebula is an edible superfruit that’s known for its use in ayurvedic as a dietary supplement to treat a wide range of health conditions, including diabetes and arthritis. In skin care, Synastol® TC is a natural and well-defined extract of Terminalia chebula. When used in topical applications, Synastol® TC is clinically proven to improve the appearance of wrinkles, repair skin barrier dysfunction, and reduce the negative effects of pollution and blue light-induced skin damage.

As an innovative, research-backed company, Sytheon is always looking for new ways to use proven ingredients to positively impact personal care. Sytheon saw the opportunity to take the beneficial, holistic characteristics of TC to the next level by developing an ultra-concentrated and standardized bioactive powder form that can be used as an oral supplement. Synastol® TC delivered in a hard gelatin capsule promises exciting benefits for customers.

Improvement in Gut Homeostasis

Gut health plays an important role in overall well-being, including skin health. When used as an oral supplement, Synastol® TC is linked to improving gut health by elevating microbiome diversity.

In a double-blind, placebo-controlled, 8-week study, subjects took 250 mg capsules of Synastol® TC twice a day to evaluate the effect of oral TC on the gut microbiome and relevant biochemical pathways. The results were statistically significant:

  • Greater alpha diversity and increased amounts of favorable gut bacteria and phages (p<0.05)
  • Increase in Akkermansia muciniphila; Expected to become a new probiotic in addition to Lactobacillusand Bifidobacterium
  • Increase in Short Chain Fatty Acid (SCFA, epigenetic regulators) production
  • Increase in serum bile acids (effectors of gut microbiome) synthesis
  • Increase in production of Acetic Acid (p=0.045)
  • Increase in production of Propionic Acid (p=0.001)
  • Increasing trend of Butyric Acid (p=0.12)

Beauty From The Inside Out

When used as an oral supplement, Synastol® TC successfully targets sebum excretion rate (linked to acne), facial erythema (redness), and wrinkles. In a double-blind, placebo-controlled, 8-week study, subjects took 250 mg capsules of Synastol® TC twice a day. The results showed:

  • 33% decrease in sebum excretion rate after 8 weeks of Synastol® TC, compared to a 29% increase with placebo.
  • Statistically significant decrease in cheek erythema after 8 weeks of Synastol® TC treatment, compared to an increase with placebo.
  • Statistically significant decrease in wrinkles after 8 weeks of Synastol® TC treatment, compared to an increase with placebo.

Overall, our findings suggest that oral supplementation with standardized TC extract with a highly enriched hydrolyzable tannins has beneficial properties for the skin, which may be due to improved gut health. These findings are published in the Journal of Clinical Medicine.

Synastol® TC is a holistic, multifunctional active that can provide helpful benefits to your customers. Request a sample to learn more about how to use TC in your product line as a nutritional supplement.

As featured in Cosmetics Business, SpecialChem, and happi

Sytheon recently published breakthrough research on acetyl zingerone and tetrahexyldecyl ascorbate’s effectiveness on skin photoaging.
Synastol® TC is a natural, safe ingredient that can now be used as a nutritional supplement, providing holistic benefits for customers.
Acetyl Zingerone is a perfect active for your next sun care product that protects the skin before, during and after sun exposure. Here’s how.
Hexylresorcinol does not pose the same dangers as resorcinol. Keep reading to understand the differences between these ingredients.
Here are the top five skin care ingredient trends that forward-thinking brands should capitalize on in 2024.
Dr. Ratan K. Chaudhuri is an innovator passionate about helping others, which led to a career in personal care and starting Sytheon in 2006.
Clinical Study: Synoxyl® AZ & VitaSynol® C on Photoaging

Clinical Study: Synoxyl® AZ & VitaSynol® C on Photoaging

In a recent article published in the Journal of Cosmetic Dermatology, researchers evaluated the effects of Synoxyl® AZ (acetyl zingerone,...

by Dr. Ratan K. ChaudhuriApril 15, 2024
Read More
New Application: Synastol® TC (Terminalia Chebula Fruit Extract) Now Available as a Nutritional Supplement

New Application: Synastol® TC (Terminalia Chebula Fruit Extract) Now Available as a Nutritional Supplement

Get Your Gut in the Game of Skin Beauty – The Science Behind Standardized Terminalia Chebula Fruit Extract for Delivering...

by Dr. Ratan K. ChaudhuriFebruary 20, 2024
Read More
How to Incorporate Acetyl Zingerone (Synoxyl® AZ) Into Your Sun Care Product Line

How to Incorporate Acetyl Zingerone (Synoxyl® AZ) Into Your Sun Care Product Line

Most consumers are aware of the dangers of sun exposure and have incorporated sunscreen into their routine as a result....

by Dr. Ratan K. ChaudhuriFebruary 8, 2024
Read More
Hexylresorcinol vs. Resorcinol: What’s the Difference?

Hexylresorcinol vs. Resorcinol: What’s the Difference?

Some beauty brands avoid using hexylresorcinol in their skin care products due to a misconception that it is closely related...

by Dr. Ratan K. ChaudhuriJanuary 24, 2024
Read More
Top 5 Skin Care Ingredient Trends for 2024

Top 5 Skin Care Ingredient Trends for 2024

What are your customers asking for in skin care products, and how can you respond to those demands? In this...

by Dr. Ratan K. ChaudhuriDecember 15, 2023
Read More
Top 6 Safe & High-Performing Skin Lightening Ingredients

Top 6 Safe & High-Performing Skin Lightening Ingredients

Consumers are always looking for new ways to promote the health and appearance of their skin. For those asking for...

by Dr. Ratan K. ChaudhuriNovember 14, 2023
Read More