Synastol® TC (INCI: Terminalia Chebula Fruit Extract) stands out as a highly versatile ingredient, offering a multitude of benefits that enable formulators to address diverse consumer needs with impactful claims.
Terminalia Chebula Fruit Extract is derived from the fruit of the Terminalia Chebula tree, commonly known as Haritaki. Haritaki fruit has been used in traditional Ayurvedic medicine for its wide range of health benefits, including antioxidant, antibacterial, anti-fungal and anti-inflammatory properties.
Synastol® TC is available for both topical and oral use, offering users a potent source of Terminalia Chebula’s active constituents, enhancing overall skin health and gut microbiome wellness.
Discover the scientific, validated versatility of Terminalia Chebula Fruit Extract.
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5 Ways Synastol® TC (INCI: Terminalia Chebula Fruit Extract) Improves Skin Health
#1. Protects and Strengthens the Skin’s Extracellular Matrix
Terminalia Chebula Fruit Extract is rich in bioactive compounds, including tannins, flavonoids, and polyphenols, which work synergistically to enhance skin health. The extract’s active ingredients smooth the skin’s surface, support cellular renewal, and provide a robust defense against oxidative stress – all critical functions to protect the ECM’s integrity.
Maintaining ECM Integrity with Synastol® TC
The extracellular matrix (ECM) is a complex and dynamic network that plays a crucial role in maintaining the skin’s composition and structural architecture. Synastol® TC supports the integrity of the ECM by influencing key biological processes and signaling pathways.
- Stimulation of ECM Components:
Synastol® TC acts as a Matrisome gene stimulator, promoting the production of essential ECM proteins, including Collagen I and III. This stimulation is vital for maintaining the skin’s structural support and resilience. - Regulation of Circadian Rhythm Genes:
The extract helps regulate circadian rhythm genes, which are crucial for optimizing cellular functions and maintaining the natural balance of skin processes throughout the day and night. - Activation of AMPK:
AMPK activators are reported to prevent formation of senescent cells and modulate multiple longevity pathways. By activating AMP-activated protein kinase (AMPK), Synastol® TC enhances cellular energy levels and metabolic processes. In fact, it’s 2X better at AMPK activation vs Resveratrol. - Reduction of Cellular Senescence:
Synastol® TC also helps reduce cellular senescence, the process where cells lose their functionality over time, contributing to healthier and more resilient skin.
Synastol® TC offers comprehensive support for maintaining ECM integrity, promoting a more youthful complexion.
Protection of the ECM
Synastol® TC helps safeguard skin’s extracellular matrix (ECM) by defending against environmental aggressors, including pollution and blue light, and as a powerful antioxidant that neutralizes pollutants and mitigates oxidative stress.
- Combats Glycation:
The glycation process where sugar molecules bind to proteins or lipids without the involvement of an enzyme can damage collagen and elastin, the proteins responsible for skin’s elasticity and firmness. Synastol® TC is 7X more effective in reducing glycation than Aminoguanidine, and 5X more effective at reversing glycation vs control. - Inhibits MMP’s
Synastol® TC helps protect collagen by inhibiting Matrix Metalloproteinases, or MMPs. These are a group of enzymes responsible for the breakdown and remodeling of extracellular matrix (ECM) components, including collagen, elastin, and proteoglycans. - Potent Antioxidant Protection
Synastol® TC is a 16X more powerful antioxidant than pomegranate. - Synastol® TC maintains its antioxidant effectiveness even under UV exposure, providing long-lasting protection against oxidative stress caused by blue light and pollution.
Synastol® TC is an advanced solution for maintaining skin health and combating environmental damage, ensuring a more resilient skin barrier.
#2. Enhances Skin Hydration
Hyaluronidase Inhibitor
Synastol® TC effectively inhibits hyaluronidase, an enzyme responsible for breaking down hyaluronic acid in the skin. By preventing the degradation, Synastol® TC helps maintain optimal levels of hyaluronic acid and supports the integrity of the ECM. The result: improved skin hydration, firmness, and overall structural resilience, ensuring a healthy, hydrated complexion.
Filaggrin Expression
Synastol® TC has been proven to boost the expression of Filaggrin (FLG), a protein crucial for maintaining the skin’s barrier function and moisture levels, by 300% after just four days (ex-vivo study). FLG degradation products (Natural Moisturizing Factors, NMF) account in part for the water-holding capacity and maintenance of acidic pH of the SC, both crucial for the epidermal barrier homeostasis.
#3. Reduces Inflammation
Synastol® TC excels in reducing inflammation induced by environmental aggressors. It works by inhibiting pro-inflammatory markers such as IL-6 and IL-8.
- What is IL-6? In the skin, IL-6 is involved in the regulation of inflammation, immune responses, and tissue regeneration. Elevated levels of IL-6 can indicate acute or chronic inflammation and are associated with various skin conditions such as psoriasis, eczema, and dermatitis.
- What is IL-8? In the skin, IL-8 is produced as a response to injury or infection. Elevated levels of IL-8 in the skin are often associated with acute inflammation, particularly in conditions like acne and wound healing.
Remarkably, Synastol® TC is up to 4X more effective than Dexamethasone, a widely used corticosteroid, in reducing these inflammatory markers. The result: healthier, more balanced complexion with reduced sensitivity and reactivity.
#4. Regulates Pigmentation
Synastol® TC is a potent inhibitor of peroxidase enzyme activity, which plays a key role in the pigmentation process. By reducing this activity, Synastol® TC effectively minimizes excessive melanin production and helps to even out skin tone. The result: noticeable reduction in pigmentation irregularities and a brighter, more uniform complexion.
#5. Supports the Gut-Skin Axis
A healthy gut microbiome is characterized by various microbial species, increased beneficial bacteria, and a balanced production of important gut metabolites. As an oral supplement, Synastol® TC significantly enhances microbiome diversity by supporting effective digestion, immune function, and general health.
Oral Supplement Gut Microbiome Benefits
In a double-blind, placebo-controlled study, participants who took 250 mg of Synastol® TC twice daily for eight weeks experienced notable improvements in these areas:
- Akkermansia muciniphila, a powerhouse probiotic that accounts for up to 4% of intestinal bacteria, helps strengthen the gut lining, improves digestive health, supports a healthy weight and produces SCFA’s. Synastol® TC Oral Supplement group showed shift in gut microbiome with increase in Akkermansia muciniphila.
- Butyric Acid, an epigenetic regulator, is known to support digestive health, reduce inflammation and lower the risk of diseases and promote overall health. It holds a significant role in providing colon cells with the needed energy to carry out their normal function and can help regulate blood sugar and cholesterol levels. Synastol ® TC Oral Supplement showed a significant increase in Butyric Acid.
- Acetic and Propionic Acids are known to regulate the acid mantle of the gut, modulate the immune response, and regulate appetite and metabolism while enhancing gut barrier function. Synastol® TC Oral Supplement showed statistically significant increase in Acetic Acid and Propionic Acids.
- High levels of Isobutyric Acid are known to be a sign of gut dysbiosis, and elevated amounts can impact pH balance and even interfere with the metabolic process. Synastol® TC Oral Supplement showed a statistically significant decrease in Isobutyric Acid.
Synastol® TC can promote healthy gut function and a balanced digestive system.
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Oral Supplement Skin-Enhancing Benefits
In the same oral supplement study, Synastol® TC users experienced a significant decrease in forehead sebum rate, reduced cheek erythema, and improved wrinkle appearance.
Unlock the Potential of Synastol® TC for Superior Skincare Solutions
Synastol® TC, or Terminalia Chebula Fruit Extract, offers a wealth of versatile skin-enhancing benefits for both topical and oral applications to create beautiful skin inside and out. By harnessing these extensive benefits, brands can label themselves as trailblazers in both innovation and naturality.
Some potential go-to-market claims with Synastol® TC included in the formulations could be:
- Boosts skin barrier function and maintains hydration
- Provides potent antioxidant protection
- Stimulates natural collagen synthesis
- Helps skin appear firmer
- Helps visibly reduce the number and severity of wrinkles
- Protects skin against environmental aggressors, like blue light and pollution
- Promotes a more even-toned complexion
- Reduces the appearance of dark circles
If you have questions about incorporating Synastol® TC into a formulation, please contact us. If you’re ready for a sample of Synastol® TC, request one here.