Clinical Study: Synastol® TC (Terminalia Chebula Fruit Extract) Supplementation Reduces Wrinkles

In a recent article published in the Journal of Clinical Medicine, Synastol® TC (INCI: Terminalia Chebula Fruit Extract) is the focus of a double-blind study to determine if oral TC fruit extract supplementation can regulate the skin’s sebum production and reduce wrinkles.

PARSIPPANY, NJ – Terminalia Chebula (TC) is a medicinal plant commonly used in Ayurveda and herbal remedies that has antioxidant, anti-inflammatory and antibacterial properties. In addition to applying TC topically on the skin for cosmetic benefits, researchers and dermatologists were interested in the effects TC would have on the skin via oral supplementation.

To investigate these potential effects, researchers conducted a double-blind, placebo-controlled clinical study using Synastol® TC (INCI: Terminalia Chebula Fruit Extract). The objective was to determine whether such supplementation could regulate sebum production and reduce the appearance of wrinkles.

The study included 38 healthy females between the ages of 25 and 65 who were given either a placebo capsule or a 250 mg capsule of Synastol® TC twice daily for eight weeks.

The results are as follows:

  • The subjects who took the TC capsules showed a 33% decrease in forehead sebum excretion rate compared to an increase of 29% in the ones who took the placebo capsules at eight weeks (p<0.01).
  • Cheek erythema showed a statistically significant decrease after eight weeks of taking the TC capsules compared to those who took the placebo.
  • The interventional group saw a statistically significant decrease in facial wrinkles compared to the placebo group as well.

In conclusion, Synastol® TC oral supplementation is an effective way to reduce facial sebum and improve the appearance of wrinkles.

To access the article, click here.

Also featured in GCI, Cosmetics & Toiletries, and SpecialChem.

About Sytheon

Sytheon is an innovative research-focused company committed to developing high-performance active ingredients for the personal care industry. Inspired by nature, all of Sytheon’s ingredients have been scientifically and clinically validated to improve the health and beauty of the skin.

Visit our website: www.sytheonltd.com

Sytheon recently published breakthrough research on acetyl zingerone and tetrahexyldecyl ascorbate’s effectiveness on skin photoaging.
Synastol® TC is a natural, safe ingredient that can now be used as a nutritional supplement, providing holistic benefits for customers.
Acetyl Zingerone is a perfect active for your next sun care product that protects the skin before, during and after sun exposure. Here’s how.
Hexylresorcinol does not pose the same dangers as resorcinol. Keep reading to understand the differences between these ingredients.
Here are the top five skin care ingredient trends that forward-thinking brands should capitalize on in 2024.
Dr. Ratan K. Chaudhuri is an innovator passionate about helping others, which led to a career in personal care and starting Sytheon in 2006.
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