ActSES®

Atopic Dermatitis Product

An Exclusive Turnkey Product for Treating Eczema

ActSES® is a unique synergistic combination product of Isosorbide di-(linoleate/oleate) (HydraSynol® IDL) + Isosorbide di-caprylate (HydraSynol® DOI), developed to serve an unmet need in Atopic Dermatitis (AD) treatment. Sytheon is seeking an exclusive partner to bring ActSES® to market. 
ActSES

ActSES® at a Glance

ActSES®

 at a Glance

Ingredients

Isosorbide Di–(Linoleate/oleate) Isosorbide Di-Caprylate

Origin

Biomimetic Synthesis

Key Results from Clinical and Consumer Studies
  • Improved itching and decrease in AD flares, leading to significant reduction of steroid use with no side effects in 5-week pilot clinical trial 
  • Increase in ActSES® group compared to vehicle group (56.5% vs 25%, p=0.07) in individuals that achieved at least a 75% improvement in their EASI score
  • Decrease in the relative abundance of Staphylococcus aureus (p=0.044) after ActSES® but not with the placebo
  • Potential to be steroid sparing for treating AD flares (Dermatitis, 2023, accepted)
  • Clinical study to determine the effect of ActSES® on children is underway 
  • Consumer study reveals hard-to-believe clearance in eczema patients
Characteristics
  • Synergistically inhibits inflammatory cascades that amplify pruritus and cutaneous eruption
  • “Outside-in” topical therapy that can complement “inside-out” systemic medications as a multifaceted treatment approach to target cutaneous pathways that predispose to AD development  
  • Preclinical validation obtained by using validated AD laboratory models that evaluated the effects of ActSES® at the histological and molecular levels
  • Cosmos Natural Certified
  • REACH registered

Key Attributes

There is currently an unmet need for a sustainable, safe, and cost-effective product for those with mild to moderate Atopic Dermatitis who may not qualify for systemic medications. Sytheon’s turnkey product, ActSES®, has solid science, patent protection, and clinical validation by UC-Davis, CA dermatologists – and a new clinical study on children underway. ActSES® technology platform can be expanded to treat other skin diseases, such as psoriasis, ichthyosis, rosacea, and more.

Patented product.

Applications

SKIN PROTECTION

Protects & Restores the Skin Barrier

CALM AND SOOTHING

Improves Itching & Decreases Flares

Publications

J Investigative Dermatology,141(6):1416-1427.e12., 2021

K Bojanowski, WR Swindell, S Cantor, RK Chaudhuri

Other Ingredients

Isosorbide Dicaprylate

Hydra Synol® DOI

A smart lipophilic skin hydrator & barrier builder

Trimethoxybenzylidene Pentanedione

Synoxyl® HSS

Synoxyl HSS

Solution to make Hawaii-compliant sunscreens

 Ethyl Linoleate

Synovea® EL

A synergist with multiple skin benefits

Caprylic/Capric Triglycerides | Ethyl Linoleate | Hexylresorcinol

Synactin® AC

5-in-1 solutions in mitigating acne-affected skin