Nov 30, 2023

Helping Others with Better Personal Care Ingredients: Sytheon’s Founder Story

At an early age, Ratan K. Chaudhuri, PhD, discovered he could leverage scientific research to improve people’s lives. This philosophy has driven Dr. Chaudhuri throughout his entire career – and represents the very fabric of Sytheon as a company.

Dr. Chaudhuri is an innovator passionate about helping others. This passion is what drove him to pursue a career in personal care and, eventually, start Sytheon in 2006. Here are some highlights about Dr. Chaudhuri’s leadership and innovation in the personal care industry.

Sytheon’s Impact on Personal Care

Since founding Sytheon, Dr. Chaudhuri and his team have developed an impressive portfolio of products that are backed by clinical data. These skin care ingredients are inspired by nature and contain anti-aging and antioxidant properties that promote healthy skin.

One of Dr. Chaudhuri’s greatest accomplishments was the invention of Sytenol® A, a 99%+ pure bakuchiol product that is the true alternative to retinol. Clinical studies showed that Sytenol® A has a better tolerability profile than retinol and is clinically proven to address multiple signs of aging. Sytenol® A is REACH-registered and the only bakuchiol approved for use in China.

Sytheon’s latest innovation is ActSES®, a turnkey product with clinical validation and patent protection, to fulfill an industry need for a sustainable, safe and cost-effective product to treat mild to moderate Atopic Dermatitis (AD). Dr. Chaudhuri hopes to find an exclusive partner to help bring ActSES® to the OTC dermatological market so children and adults with mild-to-moderate AD can find relief for their symptoms.

Sytheon’s Impact on Others

Dr. Chaudhuri’s passion for helping others extends beyond his innovative work. He also dedicates himself to others through Sytheon’s charitable activities, including benevolent research collaborations with the Moffitt Cancer Research Center and UC-Davis California.

Dr. Chaudhuri’s leadership and philosophy for helping others have allowed him to build a company that has a positive impact on the world. In recognition of this, Dr. Chaudhuri has been inducted into the Marquis Who’s Who biographical registry. Read the full Marquis Who’s Who profile here.

Nov 3, 2023

Sytheon Granted 2 New US Patents on Isosorbide Diesters for Treating Atopic Dermatitis, Seeking Exclusive Partner to Bring to Market

Sytheon is thrilled to announce that its new turnkey product for treating Atopic Dermatitis (eczema) has further patent protection – and is actively seeking an exclusive partner to bring it to the OTC dermatological market.

There is currently an unmet need for a sustainable, safe, and cost-effective product for those with mild to moderate Atopic Dermatitis (AD). Sytheon has a turnkey product, ActSES®, with solid science, patent protection, and clinical validation by UC-Davis, CA dermatologists – and a new clinical study on children underway.

Market Opportunity for Atopic Dermatitis (AD)

Topical therapies are a mainstay treatment for AD, particularly for children or those with mild-to-moderate disease who may not qualify for systemic medications. The complexity of chronic AD is increased by the interplay of skin barrier dysfunction and immune dysregulation, resulting in the perpetuation of AD signs and symptoms.

ActSES®, a unique synergistic combination product of Isosorbide di-(linoleate/oleate) (Hydra Synol® IDL) + Isosorbide di-caprylate (Hydra Synol® DOI), has been developed by Sytheon to serve this unmet need. The effects of topically applied ActSES® are not limited to barrier repair but synergistically inhibit inflammatory cascades that amplify pruritus and cutaneous eruption.

For ActSES®, Sytheon has obtained two new US patents 11,753,414 (method) & 11,753,415 (composition), entitled “Composition and Methods for Treating Atopic Dermatitis.” Sytheon has two earlier US Patents (10,597,402 & 11,312,725), which disclose “compositions and methods for restoring epidermal integrity and function and treating dermatological diseases.”

Sytheon is actively looking for an exclusive partnership with the right organization to bring this turnkey product to the OTC dermatological market. To inquire, please send us a message here.

This news piece is also featured on SpecialChem and HAPPI.

About Sytheon

Sytheon is an innovative research-focused company committed to developing high-performance active ingredients for the personal care industry. Inspired by nature, all of Sytheon’s ingredients have been scientifically and clinically validated to improve the health and beauty of the skin.

Visit our website: www.sytheonltd.com

Oct 24, 2023

Hexylresorcinol in Skin Care: Short Guide to Synovea® HR

Hexylresorcinol has a 95-year history of use in food and pharmaceuticals, but its benefits as an active ingredient for skin care applications have only begun to be realized.

In 2007, Sytheon introduced hexylresorcinol to the cosmetic market as a skin lightener and even toner under the trade name Synovea® HR. As a globally approved, highly pure active with excellent skin tolerance, Synovea® HR has become an increasingly sought after ingredient. In this blog post, we discuss:

The definition and origins of hexylresorcinol
Hexylresorcinol in the skin care industry (Synovea® HR)
4 important characteristics of Synovea® HR
Formulation examples and tips

What Is Hexylresorcinol?

Hexylresorcinol is inspired by the natural alkyresorcinols family, which are amphiphilic phenolic lipids found in the bran fractions of rye and other cereals. Produced by organic synthesis, hexylresorcinol has GRAS (Generally Recognized as Safe) status and is commonly used in the food and pharmaceutical industry.

For example, it’s known to prevent melanosis in shrimp and extend the storage life of fresh-cut fruits such as apples and mangoes. Hexylresorcinol is also used in throat lozenges to provide temporary relief to mouth and throat symptoms due to its antiseptic and anesthetic properties.

How can hexylresorcinol be used in skin care applications?

Hexylresorcinol in Skin Care: Synovea® HR

Synovea® HR is known as the gold standard in skin brightening and even toning. Its exceptional efficacy can be attributed, in part, to Sytheon’s ability to attain highly purified hexylresorcinol (>99.5-99.9%), which is essentially free of resorcinol (a known skin irritant) and its intermediate, hexanoylresorcinol.

It works by modulating at least eight sites in the melanogenesis pathway, which means it can influence melanin production at many different points. It can simulate or increase glutathione, reducing oxidative stress and resulting in mitigating the harmful effects of free radicals on the skin. It also inhibits NFκB, which addresses conditions associated with inflammation.

Here are the main applications of Synovea® HR in skin care:

Skin Lightening: Synovea® HR brightens complexions and provides effective melanin inhibitory activity. It is proven to have the most effective melanin inhibitory activity over other well-known commercial products.

Even Toning: Synovea® HR provides significant improvement in skin clarity and complexion.

Hyperpigmentation & Dark Spot Correction: Synovea® HR aids in pigment reduction without affecting the surrounding areas.

Dyspigmentation: 1% Synovea® HR has been found to match the effectiveness of 2% hydroquinone in minimizing dyspigmentation on the face and hands, without the safety concerns of hydroquinone.

Synovea® HR is the gold standard for these uses in skin care thanks to the following four characteristics.

4 Important Characteristics of Synovea® HR

#1. Excellent Safety Profile

Synovea® HR provides the best ratio between safety and performance, and it has the clinical studies to support it.

As mentioned, it has a purity level of >99%, resulting in Synovea® HR being able to interact well with all skin types. In fact, it offers the following skin protection properties:

Skin Protection: Up-regulates glutathione, glutathione peroxidase and glutathione reductase.
DNA Protection: Provides long-term protection of DNA degradation under UV light.
DNA Repair: Inhibits DNA damage and improves DNA repair via NFκB pathway.
Protein Protection: Protects collagen and other proteins by reducing Glycation.

#2. Photochemically Stable

Synovea® HR can’t be easily degraded by exposure to UV light or other forms of radiation, so it remains effective for a longer period of time. This is beneficial for both the product formula and the consumers using it. Photochemical stability extends the shelf life of the product, and consumers can use the product over a longer period of time with consistent and safe results.

#3. Clinically Validated

Like all Sytheon active ingredients, Synovea® HR has been rigorously tested to prove clinically efficacy and safety.

Some key results from clinical studies include:

Explore the full list of research supporting Synovea® HR here.

#4. Multifunctional

Synovea® HR is a true multifunctional active that can address multiple skin concerns due to its diverse range of actions on the skin, including reducing melanin production, neutralizing free radicals, stimulating collagen production, and more.

Hexylresorcinol has clear applications in skin care, and Synovea® HR stands out as a high performing, safe, and versatile active. Here’s how to use it in your next formula.

How to Formulate with Synovea® HR

There are many different types of formulas that Synovea® HR can be used in as the main active ingredient, including creams, serums, and lotions.

It can also be combined with other ingredients to enhance the benefits. Here are two examples:

#1. Even Toner Cream with Synovea® HR and Synovea® EL

Ethyl linoleate is a very good solubilizer for hexylresorcinol. It’s clinically proven to lighten UV-induced skin pigmentation by accelerating post-translational proteolytic degradation of tyrosinase.

By adding Synovea® HR and Synovea® EL (Ethyl Linoleate) to the skin-friendly emollient Caprylic/Capric Triglycerides, Sytheon has created an elegant, easy-to-use and very cost-effective synergistic skin lightening blend: Asyntra® SL. Asyntra® SL’s recommended use level is 2 to 4% and is commonly used in even toner creams.

#2. Dark Spot Corrector with Synovea® HR and Niacinamide

Niacinamide is a multifunctional ingredient that works well with all skin types and concerns. Specifically, it’s known to minimize enlarged pores, add moisture, and brighten skin. It can be formulated alongside Synovea® HR to enhance its skin brightening and even toning benefits. For example, Synovea® HR and niacinamide make a powerhouse dark spot corrector.

Here are some other tips about formulating with Synovea® HR:

Suggested use level: 0.5 to 1.0%
Recommended pH: <6
Pre-solubilize in appropriate solvent before adding to the final formulation
Oil-soluble ingredients: hydrophobic emollient esters and other high polarity esters, Hydra Synol® DOI, Caprylic/Capric Triglycerides, and Synovea® EL
Water-soluble ingredients: Ethoxydiglycol, Butylene Glycol, non-ionic solubilizers, glycerol, and a wide range of glycols
Not recommended with Ethanol

Conclusion

Hexylresorcinol is a well-researched, established ingredient with applications across many industries. For beauty brands seeking to use hexylresorcinol for skin brightening and even toning properties in their next skin care formula, Synovea® HR is the best choice. It’s globally approved, REACH registered, and patented, and multiple clinical studies with Synovea® HR demonstrated its strong performance in skin brightening and hyperpigmentation control for all skin types.

Sytheon is a research-backed developer of high-performance active ingredients, including Synovea® HR. Request a sample today.

Sep 28, 2023

Synastol® TC (Terminalia Chebula Fruit Extract): A Multifunctional Ingredient for Well-Aging Products

In a recent study published in the International Journal of Cosmetic Science, Pierre Fabre researchers evaluated the effects of Synastol® TC on Senomorphic Targets.

Terminalia Chebula Fruit Extract (TC) is an all-natural ingredient that is reproducibly manufactured using a standardized and well-defined process. Earlier studies by Sytheon revealed that TC induced multiple skin benefits by altering tissue architecture, enhancing cutaneous circadian rhythm, reversing protein glycation, strengthening barrier formation, and elevating two key hydration biomarkers, including Filaggrin & Aquaporin-9. Clinically, TC provided visible reduction in signs of facial aging and reversed pollution-induced skin damage. TC is globally approved and certified by ECOCERT COSMOS NATURAL.

Aged skin shows structural, cellular, and molecular changes along with accumulation of senescent cells, which cease to proliferate while remaining metabolically active. Senescent cells secrete a range of inflammatory cytokines, chemokines, proteinases, and small extracellular vesicles (EV) containing miRNAs, collectively called the Senescent Associated Secretary Phenotype (SASP). Skin senescent cells accumulate progressively with age and exert direct impacts on skin structure and function.

Pierre Fabre scientists used senescent human dermal fibroblast (HDF) cells to demonstrate the effects of TC in reversing SASP. Briefly, senescence was induced by exposing HDF cells to ionizing radiation followed by 14-days of incubation with or without TC. Senescence was assessed on day 14 regarding cell morphology, β-galactosidase activity, SASP genes and miRNAs contained in EVs to evaluate beneficial effects of TC compared with untreated controls.

Compared with the untreated controls, treatment of senescent cells with TC exhibited statistically significant down-regulation of β-galactosidase activity along with down regulation of genes related to SASP chemokines, cytokines, and the proteolytic mediator MMP-1. Additionally, TC-treated senescent cells exhibited a strong reduction in key miRNAs in secreted EVs.

In conclusion, this work demonstrates that Synastol® TC bestows strong senomorphic properties, which further validates Sytheon’s earlier mechanistic and clinical studies that show how TC affords positive attributes to skin that are not merely superficial but deep and multi-targeted.

The study was also featured on SpecialChem.

Sep 8, 2023

Science Meets Beauty: 10 Active Ingredients that Will Enhance Your Skincare Formulation

Today’s personal care consumers are vigilant about the ingredients used in their favorite skincare products. They want to know exactly what’s in the product and how well it will work. To meet these needs, beauty brands must use active ingredients that are scientifically proven to perform.

Why Science Matters in Skincare Active Ingredients

A recent study found that 53 percent of U.S. beauty and personal care users research ingredients to better understand the effectiveness of products. They want to know exactly what’s in the product and how it works before making an investment. Beauty brands can satisfy consumer needs by using active ingredients that have clinical data to back up their claims.

Clinical data, which has been gathered by controlled experiments and assessments, provides valuable insights into the way active ingredients perform. Qualified researchers and dermatologists collect this data and can also reveal how certain actives react to the skin, including their effects on various skin conditions.

Consumers are less likely to purchase products without any science to back up the ingredient claims but will seek out alternative products that do have the proper data.

When consumers research the ingredients in your product, will they find reputable studies that confirm the actives perform as advertised? If not, it’s time to consider replacing them with clinically-backed ingredients. Here are 10 choices to consider for different types of benefits.

10 Active Ingredients that Will Enhance Your Skincare Formulation

1. Sytenol® A: The Best Bakuchiol

Sytenol® A (INCI: Bakuchiol) is a pure, well-defined compound that’s sustainably extracted from the seeds of the Babchi plan (Psoralea corylifolia). It’s the gold standard for bakuchiol with 99%+ purity, and it’s the only REACH-registered and China-approved bakuchiol with a complete toxicology dossier.

Not all bakuchiol is created equal. The purity level of Bakuchiol determines its effectiveness and the severity of its side effects. For example, pure bakuchiol has minimal to no side effects. However, less pure bakuchiol can cause more serious problems, such as contact dermatitis and photosensitivity.

To protect your brand and give your customers the best results, consider Sytenol® A when you want bakuchiol in your formulation. Your customers will thank you.

2. Synoxyl® AZ: Microbiome Friendly, 24/7 Prevention & Repair of Skin Damage

Synoxyl® AZ (INCI: Acetyl Zingerone) is an organically synthesized, multi-targeted ingredient that counteracts aging before it occurs and helps to reverse signs of photo-damaged skin. It’s an antioxidant, quencher, and selective chelator that enhances the skin’s defenses against natural and environmental stressors.

Clinical study participants who used Synoxyl® AZ saw a significant decrease in average wrinkle severity, total wrinkle volume, pigment intensity, and redness intensity. As a result, Synoxyl® AZ offers a noteworthy advancement in the development of a more effective molecule that targets skin aging.

3. Synovea® HR: The Gold Standard in Skin Brightening & Even Toning

Synovea® HR (INCI: Hexylresorcinol) is a powerful, organically synthesized ingredient that ushers in a new standard for skin lightening. It helps to brighten the skin’s complexion and correct dark spots by modulating a minimum of eight sites in the melanogenesis pathway. Synovea® HR also stimulates glutathione and inhibits NFkB to delay cell cycle progression.

Researchers compared Synovea® HR and hydroquinone in their effectiveness for remedying dyspigmentation, an abnormality that results in dark spots on the skin. Hydroquinone is a popular treatment method for dyspigmentation, but it comes with potential safety issues. Researchers wanted to see if Synovea® HR performed better without the safety concerns, so they gave participants either topical 1% Synovea® HR or topical 2% hydroquinone.

The results found that applying 1% Synovea® HR topically presents a well-tolerated solution that matches the effectiveness of 2% hydroquinone in minimizing dyspigmentation on the face and hands. When you need a safe and effective ingredient to combat dyspigmentation, Synovea® HR is the ideal choice.

4. Synastol® TC: The Holistic Solution to Pollution & Blue Light-Induced Skin Damage With Anti-Aging Benefits

Synastol® TC (INCI: Terminalia Chebula Fruit Extract) is a well-defined extract from the hyperfruit Terminalia chebula. It’s clinically proven to improve the appearance of fine lines, wrinkles, and eye areas while also reducing the negative effects of pollution and blue light-induced skin damage.

For example, researchers conducted a study to see if topical Synastol® TC could protect against and repair pollution-induced skin damage. The results showed that Synastol® TC offered longer-lasting and more efficient neutralization of reactive oxygen species (ROS) compared to tocopherol. Synastol® TC also offered significant improvements in skin texture, hydration, tone, firmness, and radiance, which validated its ability to restore and prevent skin damage caused by environmental pollution.

Another study determined whether an oral form of Synastol® TC could regulate the skin’s sebum production and reduce wrinkles. Researchers and dermatologists discovered that subjects who received the TC capsules had a reduction in forehead sebum excretion rate, cheek erythema, and facial wrinkles over the course of eight weeks compared to subjects who received the placebo capsules.

When you need an effective ingredient with anti-aging benefits, consider Synastol® TC for your formulation.

5. Hydra Synol® DOI: A Smart Lipophilic Skin Hydrator & Barrier Builder

Hydra Synol® DOI (INCI: Isosorbide Dicaprylate) is a plant-based ingredient that intelligently hydrates and defends the skin. It’s also a natural and biodegradable alternative to phenyl trimethicone for ultimate hair shine.

Researchers studied Hydra Synol® DOI’s ability to improve water homeostasis and epidermal barrier function in the skin. They compared 2% of Hydra Synol® DOI lotion with 2% glycerol lotion. The result? Hydra Synol® DOI proved to be the superior skin hydration solution. Researchers also found that Hydra Synol® DOI positively modulated the genes involved with maintaining skin structure and function, leading to better clinical outcomes.

Incorporate Hydra Synol® DOI into your formulation when you want a versatile ingredient that offers unmatched skin hydration and defense.

6. VitaSynol® C: Stable & Bioavailable Vitamin C

VitaSynol® C (INCI: Tetrahexyldecyl Ascorbate) is a stable, oil-soluble Vitamin C ester. Upon Vitamin C release, VitaSynol® C effectively mitigates cellular damage, scavenges reactive oxygen species (ROS), and inhibits UV-induced melanogenesis. For achieving the best results, VitaSynol® C should be paired with an antioxidant like Synoxyl® AZ or Sytenol® A.

Combining VitaSynol® C with Synoxyl® AZ helps to stabilize the formulation and improve collagen production and antioxidant effects. This development brings VitaSynol® C significantly closer to realizing its complete potential as an active component in topical formulations.

7. Synoxyl® HSS: The Solution to Making Hawaii-Compliant Sunscreens

Synoxyl® HSS (INCI: Trimethoxybenzylidene Pentanedione) is a patented ingredient that’s an SPF booster for both organic and inorganic sunscreens. It’s the ideal ingredient for creating sunscreens without octocrylene and oxybenzone, which many beauty brands are avoiding due to the possible human health and environmental risks. By decreasing the amount of sunscreens used, formulas become much more cost-effective with the addition of Synoxyl® HSS.

Researchers incorporated Synoxyl® HSS into a broad-spectrum sunscreen formulation that included avobenzone, a chemical compound known for effectively absorbing a broad range of ultraviolet a (UVA) wavelengths. They discovered Synoxyl® HSS is an efficacious photostabilizer that boosts in-vivo SPF by >50% for organic and inorganic sunscreens.

Use Synoxyl® HSS in your formula to enhance the efficacy of sunscreens while yielding cost savings during formulation.

8. Synovea® EL: A Synergist With Multiple Skin Benefits

Synovea® EL (INCI: Ethyl Linoleate) is a neutral, lipid-soluble stable form of linoleic acid with various benefits:

Maintains stratum corneum acidity
Protects barrier function
Decreases sebaceous gland activity
Regulates follicular keratinization
Inhibits post-inflammatory hyperpigmentation
Reduces skin pigmentation

Synovea® EL diminishes the activity of genes linked to cell-cell adhesion, skin development, and inflammatory response. This makes Synovea® EL the perfect ingredient for acne prevention, skin rejuvenation, and skin texturization.

9. Asyntra® D-Stress: Destress Your Skin

Asyntra® D-Stress (INCI: Isosorbide Dicaprylate and Bakuchiol and Ethyl Linoleate) is a plant-based, patent-pending ingredient that can work solo or in tandem with CBD and hemp oil. Its healing effects reduce the presence of the stress-inducing marker “cortisol,” a driver of inflammation. Simultaneously, Asyntra® D-Stress reinforces the skin’s barrier function, resulting in a visibly smoother, well-hydrated, and more radiant complexion.

One study evaluated the effects of cannabidiol (CBD) in keratinocytes (KCs) and compared them with Asyntra® D-Stress, Sytenol® A, and Synovea® EL. Sytenol® A and Synovea® EL are two key components in Asyntra® D-Stress, and researchers wanted to see how the ingredients performed individually versus in combination. It was proven that there was synergy between the two ingredients, resulting in Asyntra® D-Stress being more effective than Sytenol® A and Synovea® EL alone at:

Enhancing the bliss molecule anandamide by reducing degradation enzymes and transport proteins
Inhibiting downstream inflammatory mediators such as TNF, COX-2, and type 1 IFN
Reducing cortisol and IL-8 secretion in reconstituted human epidermis skin, which was not observed with CBD alone
Providing compensatory effects to buffer against loss of keratinocyte differentiation and protect against skin barrier compromise

These findings prove that Asyntra® D-Stress is a safe and effective alternative to CBD in your formulation.

10. Synactin® AC: 5-in-1 Solutions in Mitigating Acne-Affected Skin

Synactin® AC (INCI: Caprylic/Capric Triglycerides and Ethyl Linoleate and Hexylresorcinol) is a synergistic blend that targets acne-affected skin. It mitigates all five key acne targets:

Hyper-keratinization
Bacterial population
Sebum control
Inflammation
Pigmentation

Synactin® AC was found to help significantly reduce the appearance of acne lesions and improve skin texture. It also proved to greatly reduce skin redness.

When you want to provide consumers with an effective anti-acne product, consider adding Synactin® AC to your formulation for successful results.

Conclusion

With a keen focus on efficacy, today’s beauty enthusiasts demand skincare products that promise results and are grounded in science.

This demand has given rise to a new era of beauty brands that are dedicated to incorporating science-backed active ingredients into their formulations, ensuring their products deliver on their promises.

Refine your skincare products with clinically proven active ingredients from Sytheon. Try one of our ingredients in your formulation when you request a sample.

ABOUT SYTHEON

Our value drivers

Our mission

Awards

Our partners

R&D

Production​

Safety

Human Clinical

Regulatory

Intellectual Property & Trademark

Sytheon’s Impact on Personal Care

Sytheon’s Impact on Others

Market Opportunity for Atopic Dermatitis (AD)

About Sytheon

What Is Hexylresorcinol?

Hexylresorcinol in Skin Care: Synovea® HR

4 Important Characteristics of Synovea® HR

#1. Excellent Safety Profile

#2. Photochemically Stable

#3. Clinically Validated

#4. Multifunctional

How to Formulate with Synovea® HR

Conclusion

Today’s personal care consumers are vigilant about the ingredients used in their favorite skincare products. They want to know exactly what’s in the product and how well it will work. To meet these needs, beauty brands must use active ingredients that are scientifically proven to perform.

Why Science Matters in Skincare Active Ingredients

10 Active Ingredients that Will Enhance Your Skincare Formulation

1. Sytenol® A: The Best Bakuchiol

2. Synoxyl® AZ: Microbiome Friendly, 24/7 Prevention & Repair of Skin Damage

3. Synovea® HR: The Gold Standard in Skin Brightening & Even Toning

4. Synastol® TC: The Holistic Solution to Pollution & Blue Light-Induced Skin Damage With Anti-Aging Benefits

5. Hydra Synol® DOI: A Smart Lipophilic Skin Hydrator & Barrier Builder

6. VitaSynol® C: Stable & Bioavailable Vitamin C

7. Synoxyl® HSS: The Solution to Making Hawaii-Compliant Sunscreens

8. Synovea® EL: A Synergist With Multiple Skin Benefits

9. Asyntra® D-Stress: Destress Your Skin

10. Synactin® AC: 5-in-1 Solutions in Mitigating Acne-Affected Skin

Conclusion

Sytheon, a global supplier of unique and multifunctional active ingredients, is thrilled to announce its participation at this year’s Suppliers’ Day in Singapore.

Inspired By Nature.

Built For Performance.

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