Sytheon Publishes a Detailed Mechanistic Study on Synastol® TC

Publication: WS Swindell, K Bojanowski and RK Chaudhuri, A standardized Terminalia chebula fruit extract alters the expression of genes associated with skin architecture and barrier formation, European J Dermatology, 2020, doi: 10.1684/ejd.2020.3882

Abstract: Genome-wide expression responses to a standardized tannin-enriched extract, called Synastol® TC, were investigated in three-dimensional reconstituted human skin tissues through microarray studies. TC responses were the opposite to those observed in cells exposed to oxidative stress, solar-simulated UV radiation, and wounding, with increased expression of genes associated with water homeostasis, skin barrier establishment, blood vessel development, and circadian rhythms when compared to tissues treated with water. Also, the key keratinocyte (KC) differentiation makers FLG & LOR and hydration marker AQP9 were further confirmed at mRNA and protein levels. Consistent with these results, TC increased the expression of transcription factors regulating KC differentiation (FOS, GHRL3, PPARG) as well as key genes involved in skin architecture, such as collagens (COL1A1, COL1A2, COL5A1, COL6A6, COL6A3, COL6A1), proteoglycans (PRELP, OGN), and other matrisomes. Interestingly, recent studies showed that Collagen type VI plays a dual role in ECM functions and also has innate immune functions with activity against S. aureus, S.pneumonia, E. coli & P. aeruginosa. In separate assays, TC also inhibited MMP enzymes (MMP-1, MMP-2, MMP-3, MMP-9, MMP-12).

Overall, the results from these studies validate that Synastol® TC stimulates positive modifications within skin that are not merely superficial but deep and multi-targeted. The combined targeting of several endpoints provides better chances of delivering true benefits in skin, in sharp contrast to the old one-product-one-target dogma (mostly from undefined extracts) that currently permeates the cosmetic industry.

About Synastol® TC: Terminalia chebula fruit extract is a well-known herb in Ayruveda and is well explored for its benefits. In Tibetans, TC is highly revered for its purifying attributes; in fact, its fruit is depicted in the hands of the medicine Budha. Synastol® TC is a standardized hydrolysable tannin-enriched Terminalia chebula fruit extract. The water-soluble extract contains >60% hydrolysable tannins including Chebulinic and Chebulagic acids. Both components provide long-lasting antioxidant properties and work through biological mechanisms that provide preventative and restorative anti-aging and skin-toning benefits.

For more information, please send your inquiry to info@sytheonltd.com

Bakuchiol is a multifunctional ingredient that offers various benefits to skin care customers. It's even more powerful when paired with other actives.
Sytheon recently published breakthrough research on acetyl zingerone and tetrahexyldecyl ascorbate’s effectiveness on skin photoaging.
Learn how Bakuchiol works in skin care formulas – and how well it works for your customers – in this helpful guide for beauty brands.
Bakuchiol is known as a natural alternative to retinol. What else do skin care and beauty brands need to know about it? Here’s a complete guide to Bakuchiol 101.
Synastol® TC is a natural, safe ingredient that can now be used as a nutritional supplement, providing holistic benefits for customers.
5 Ways to Formulate with Bakuchiol for Even More Benefits

5 Ways to Formulate with Bakuchiol for Even More Benefits

Bakuchiol is a diverse, multifunctional ingredient that offers game-changing benefits to your customers, and it’s even more powerful when paired...

by Dr. Ratan K. ChaudhuriApril 29, 2024
Read More
How Bakuchiol Works: Formulation Tips for Brands & Results

How Bakuchiol Works: Formulation Tips for Brands & Results

Bakuchiol promises great benefits to customers of any skin type. How does it work? Here’s how to formulate with Bakuchiol...

by Dr. Ratan K. ChaudhuriMarch 28, 2024
Read More
Bakuchiol 101: Everything Skin Care & Beauty Brands Need to Know

Bakuchiol 101: Everything Skin Care & Beauty Brands Need to Know

Bakuchiol is known as a natural alternative to retinol. What else do skin care and beauty brands need to know...

by Dr. Ratan K. ChaudhuriMarch 13, 2024
Read More
Where Does Bakuchiol Come From? [Short Guide for Beauty Brands]

Where Does Bakuchiol Come From? [Short Guide for Beauty Brands]

Bakuchiol has been all the rage for consumers seeking a natural alternative to retinol for sensitive skin. In this short...

by Dr. Ratan K. ChaudhuriDecember 21, 2023
Read More
Creating a Trustworthy Bakuchiol Product: 3 Red Flags to Avoid

Creating a Trustworthy Bakuchiol Product: 3 Red Flags to Avoid

Bakuchiol is at the top of the list for consumers looking for a natural alternative to retinol, offering all the...

by Dr. Ratan K. ChaudhuriNovember 27, 2023
Read More
The Future of Sytenol® A with Beiersdorf in China: PCT 2023 Recap

The Future of Sytenol® A with Beiersdorf in China: PCT 2023 Recap

Sytenol® A (INCI: Bakuchiol) is making its way around the world – especially as the only source of Bakuchiol now...

by Dr. Ratan K. ChaudhuriAugust 29, 2023
Read More