Sytheon Publishes a Detailed Mechanistic Study on Synastol® TC

Publication: WS Swindell, K Bojanowski and RK Chaudhuri, A standardized Terminalia chebula fruit extract alters the expression of genes associated with skin architecture and barrier formation, European J Dermatology, 2020, doi: 10.1684/ejd.2020.3882

Abstract: Genome-wide expression responses to a standardized tannin-enriched extract, called Synastol® TC, were investigated in three-dimensional reconstituted human skin tissues through microarray studies. TC responses were the opposite to those observed in cells exposed to oxidative stress, solar-simulated UV radiation, and wounding, with increased expression of genes associated with water homeostasis, skin barrier establishment, blood vessel development, and circadian rhythms when compared to tissues treated with water. Also, the key keratinocyte (KC) differentiation makers FLG & LOR and hydration marker AQP9 were further confirmed at mRNA and protein levels. Consistent with these results, TC increased the expression of transcription factors regulating KC differentiation (FOS, GHRL3, PPARG) as well as key genes involved in skin architecture, such as collagens (COL1A1, COL1A2, COL5A1, COL6A6, COL6A3, COL6A1), proteoglycans (PRELP, OGN), and other matrisomes. Interestingly, recent studies showed that Collagen type VI plays a dual role in ECM functions and also has innate immune functions with activity against S. aureus, S.pneumonia, E. coli & P. aeruginosa. In separate assays, TC also inhibited MMP enzymes (MMP-1, MMP-2, MMP-3, MMP-9, MMP-12).

Overall, the results from these studies validate that Synastol® TC stimulates positive modifications within skin that are not merely superficial but deep and multi-targeted. The combined targeting of several endpoints provides better chances of delivering true benefits in skin, in sharp contrast to the old one-product-one-target dogma (mostly from undefined extracts) that currently permeates the cosmetic industry.

About Synastol® TC: Terminalia chebula fruit extract is a well-known herb in Ayruveda and is well explored for its benefits. In Tibetans, TC is highly revered for its purifying attributes; in fact, its fruit is depicted in the hands of the medicine Budha. Synastol® TC is a standardized hydrolysable tannin-enriched Terminalia chebula fruit extract. The water-soluble extract contains >60% hydrolysable tannins including Chebulinic and Chebulagic acids. Both components provide long-lasting antioxidant properties and work through biological mechanisms that provide preventative and restorative anti-aging and skin-toning benefits.

For more information, please send your inquiry to info@sytheonltd.com

Dr. Ratan K. Chaudhuri is an innovator passionate about helping others, which led to a career in personal care and starting Sytheon in 2006.
Sytheon is actively seeking an exclusive partner to bring its new turnkey product for treating Atopic Dermatitis (eczema) to market.
Hexylresorcinol's benefits as an active ingredient for skin care applications have only begun to be realized.
In a recent study, Pierre Fabre researchers evaluated the effects of Synastol® TC (Terminalia Chebula Fruit Extract) on Senomorphic Targets.
To meet consumer needs, beauty brands must use skincare active ingredients that are scientifically proven to perform.
Sytheon, a global supplier of unique and multifunctional active ingredients, is participating in this year’s Suppliers’ Day in Singapore.
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