Our skin has a rhythm of its own, echoing the wider rhythms of life, and when we tap into that pulse, we tap into deep beauty. Skin homeostasis and regeneration is partly controlled by molecular time-keeping mechanisms driven by external factors such as sunlight and ambient temperature .
Our continued research on Synastol® TC (INCI: Terminalia chebula fruit extract) using three-dimensional reconstituted human epidermis showed that Synastol® TC upregulates expression of genes important for circadian rhythm control, including period circadian regulators (PER1, PER2), basic helix-loop-helix transcription factors (BHLHE40/DEC1, BHLHE41/DEC2), and nuclear hormone receptors (RORA, RORC). Upregulation of some of these genes have been validated by PCR array. This effect of TC has functional significance since clock gene oscillations in skin decay with increased age, concurrent with loss of regenerative capacity and ECM structural degradation . Dysregulation of circadian rhythms with aging may also contribute to loss of DNA repair and development of skin cancers [3-5].
Modulation of circadian gene expression by Synastol® TC further validates its effect on skin is not superficial but skin deep and multi-targeted. The combined targeting of several endpoints provides better chances of delivering true skin beneficial effects, in sharp contrast to the one-product (mostly undefined extract)-one-target dogma that currently permeates the cosmetic industry.
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- Matsui et al., Biol Rhythms in the Skin, Internl J Molecular Sci, 17(6):801, 2016
- Sandu et al., Circadian clocks in rat skin and dermal fibroblasts: differential effects of aging, temperature and melatonin. Cellular and molecular life sciences,72(11):2237-2248, 2015
- Gutierezz & Arbesman, Circadian Dysrhythmias, Physiological Aberrations, and the Link to Skin Cancer, Internl J Molecular Sci, 17(5):621, 2016
- Plikus et al. The circadian clock in skin: implications for adult stem cells, tissue regeneration, cancer, aging, and immunity, J Biol Rhythms, 30(3):163-182, 2015
- Gaddameedhi et al., Control of skin cancer by the circadian rhythm, Proc National Acad Sci, USA, 108(46):18790-18795, 2011