PRODUCT	INCI NAME
Synoxyl® AZ	Acetyl Zingerone

PRODUCT	INCI NAME
Sytenol® A Synactin® AC	Bakuchiol Caprylic/Caprylic Acid and Ethyl Linoleate and Hexylresorcinol

PRODUCTS	INCI NAME
Sytenol® A Synastol® TC Synoxyl® AZ VitaSynol® C	Bakuchiol Terminalia Chebula Fruit Extract Acetyl Zingerone Tetrahexyldecyl Ascorbate

PRODUCTS	INCI NAME
Synastol® TC Synoxyl® AZ	Terminalia Chebula Fruit Extract Acetyl Zingerone

PRODUCT	INCI NAME
HydraSynol® DOI Synoxyl® HSS	Isosorbide Dicaprylate Trimethoxybenzylidene Pentanedione

PRODUCT	INCI NAME
Synovea® HR Synovea® EL Asyntra® SL Sytenol® A Synoxyl® AZ	Hexylresorcinol Ethyl Linoleate Caprylic/Caprylic Triglycerides and Hexylresorcinol and Ethyl Linoleate Bakuchiol Acetyl Zingerone

PRODUCT	INCI NAME
HydraSynol® DOI	Isosorbide Dicaprylate

PRODUCT	INCI NAME
Asyntra® D-Stress Sytenol® A HydraSynol® DOI	Isosorbide Dicaprylate & Bakuchiol & Ethyl Linoleate Bakuchiol Isosorbide Dicaprylate

PRODUCT	INCI NAME
HydraSynol® DOI Asyntra® D-Stress Synovea® EL Synastol® TC	Isosorbide Dicaprylate Isosorbide Dicaprylate and Bakuchiol and Ethyl Linoleate Ethyl Linoleate Terminalia Chebula Fruit Extract

PRODUCT	INCI NAME
HydraSynol® DOI Asyntra® D-Stress Synovea® EL Synastol® TC	Isosorbide Dicaprylate Isosorbide Dicaprylate and Bakuchiol and Ethyl Linoleate Ethyl Linoleate Terminalia Chebula Fruit Extract

PRODUCT	INCI NAME
Synovea® HR Synovea® EL Asyntra® SL Sytenol® A Synoxyl® AZ Synastol® TC	Hexylresorcinol Ethyl Linoleate Caprylic/Caprylic Triglycerides and Hexylresorcinol and Ethyl Linoleate Bakuchiol Acetyl Zingerone Terminalia Chebula Fruit Extract

PRODUCT	INCI NAME
Synoxyl® AZ Sytenol® A Synoxyl® HSS	Acetyl Zingerone Bakuchiol Trimethoxybenzylidene Pentanedione

PRODUCT	INCI NAME
HydraSynol® DOI	Isosorbide Dicaprylate

PRODUCT	INCI NAME
Synoxyl® HSS	Trimethoxybenzylidene Pentanedione

PRODUCT	INCI NAME
Synovea® HR Synovea® EL Asyntra® SL Synastol® TC	Hexylresorcinol Ethyl Linoleate Caprylic/Caprylic Triglycerides and Hexylresorcinol and Ethyl Linoleate Terminalia Chebula Fruit Extract

Sep 28, 2023

Synastol® TC (Terminalia Chebula Fruit Extract): A Multifunctional Ingredient for Well-Aging Products

In a recent study published in the International Journal of Cosmetic Science, Pierre Fabre researchers evaluated the effects of Synastol® TC on Senomorphic Targets.

Terminalia Chebula Fruit Extract (TC) is an all-natural ingredient that is reproducibly manufactured using a standardized and well-defined process. Earlier studies by Sytheon revealed that TC induced multiple skin benefits by altering tissue architecture, enhancing cutaneous circadian rhythm, reversing protein glycation, strengthening barrier formation, and elevating two key hydration biomarkers, including Filaggrin & Aquaporin-9. Clinically, TC provided visible reduction in signs of facial aging and reversed pollution-induced skin damage. TC is globally approved and certified by ECOCERT COSMOS NATURAL.

Aged skin shows structural, cellular, and molecular changes along with accumulation of senescent cells, which cease to proliferate while remaining metabolically active. Senescent cells secrete a range of inflammatory cytokines, chemokines, proteinases, and small extracellular vesicles (EV) containing miRNAs, collectively called the Senescent Associated Secretary Phenotype (SASP). Skin senescent cells accumulate progressively with age and exert direct impacts on skin structure and function.

Pierre Fabre scientists used senescent human dermal fibroblast (HDF) cells to demonstrate the effects of TC in reversing SASP. Briefly, senescence was induced by exposing HDF cells to ionizing radiation followed by 14-days of incubation with or without TC. Senescence was assessed on day 14 regarding cell morphology, β-galactosidase activity, SASP genes and miRNAs contained in EVs to evaluate beneficial effects of TC compared with untreated controls.

Compared with the untreated controls, treatment of senescent cells with TC exhibited statistically significant down-regulation of β-galactosidase activity along with down regulation of genes related to SASP chemokines, cytokines, and the proteolytic mediator MMP-1. Additionally, TC-treated senescent cells exhibited a strong reduction in key miRNAs in secreted EVs.

In conclusion, this work demonstrates that Synastol® TC bestows strong senomorphic properties, which further validates Sytheon’s earlier mechanistic and clinical studies that show how TC affords positive attributes to skin that are not merely superficial but deep and multi-targeted.

Sep 8, 2023

Science Meets Beauty: 10 Active Ingredients that Will Enhance Your Skincare Formulation

Today’s personal care consumers are vigilant about the ingredients used in their favorite skincare products. They want to know exactly what’s in the product and how well it will work. To meet these needs, beauty brands must use active ingredients that are scientifically proven to perform.

Why Science Matters in Skincare Active Ingredients

A recent study found that 53 percent of U.S. beauty and personal care users research ingredients to better understand the effectiveness of products. They want to know exactly what’s in the product and how it works before making an investment. Beauty brands can satisfy consumer needs by using active ingredients that have clinical data to back up their claims.

Clinical data, which has been gathered by controlled experiments and assessments, provides valuable insights into the way active ingredients perform. Qualified researchers and dermatologists collect this data and can also reveal how certain actives react to the skin, including their effects on various skin conditions.

Consumers are less likely to purchase products without any science to back up the ingredient claims but will seek out alternative products that do have the proper data.

When consumers research the ingredients in your product, will they find reputable studies that confirm the actives perform as advertised? If not, it’s time to consider replacing them with clinically-backed ingredients. Here are 10 choices to consider for different types of benefits.

10 Active Ingredients that Will Enhance Your Skincare Formulation

1. Sytenol® A: The Best Bakuchiol

Sytenol® A (INCI: Bakuchiol) is a pure, well-defined compound that’s sustainably extracted from the seeds of the Babchi plan (Psoralea corylifolia). It’s the gold standard for bakuchiol with 99%+ purity, and it’s the only REACH-registered and China-approved bakuchiol with a complete toxicology dossier.

Not all bakuchiol is created equal. The purity level of Bakuchiol determines its effectiveness and the severity of its side effects. For example, pure bakuchiol has minimal to no side effects. However, less pure bakuchiol can cause more serious problems, such as contact dermatitis and photosensitivity.

To protect your brand and give your customers the best results, consider Sytenol® A when you want bakuchiol in your formulation. Your customers will thank you.

2. Synoxyl® AZ: Microbiome Friendly, 24/7 Prevention & Repair of Skin Damage

Synoxyl® AZ (INCI: Acetyl Zingerone) is an organically synthesized, multi-targeted ingredient that counteracts aging before it occurs and helps to reverse signs of photo-damaged skin. It’s an antioxidant, quencher, and selective chelator that enhances the skin’s defenses against natural and environmental stressors.

Clinical study participants who used Synoxyl® AZ saw a significant decrease in average wrinkle severity, total wrinkle volume, pigment intensity, and redness intensity. As a result, Synoxyl® AZ offers a noteworthy advancement in the development of a more effective molecule that targets skin aging.

3. Synovea® HR: The Gold Standard in Skin Brightening & Even Toning

Synovea® HR (INCI: Hexylresorcinol) is a powerful, organically synthesized ingredient that ushers in a new standard for skin lightening. It helps to brighten the skin’s complexion and correct dark spots by modulating a minimum of eight sites in the melanogenesis pathway. Synovea® HR also stimulates glutathione and inhibits NFkB to delay cell cycle progression.

Researchers compared Synovea® HR and hydroquinone in their effectiveness for remedying dyspigmentation, an abnormality that results in dark spots on the skin. Hydroquinone is a popular treatment method for dyspigmentation, but it comes with potential safety issues. Researchers wanted to see if Synovea® HR performed better without the safety concerns, so they gave participants either topical 1% Synovea® HR or topical 2% hydroquinone.

The results found that applying 1% Synovea® HR topically presents a well-tolerated solution that matches the effectiveness of 2% hydroquinone in minimizing dyspigmentation on the face and hands. When you need a safe and effective ingredient to combat dyspigmentation, Synovea® HR is the ideal choice.

4. Synastol® TC: The Holistic Solution to Pollution & Blue Light-Induced Skin Damage With Anti-Aging Benefits

Synastol® TC (INCI: Terminalia Chebula Fruit Extract) is a well-defined extract from the hyperfruit Terminalia chebula. It’s clinically proven to improve the appearance of fine lines, wrinkles, and eye areas while also reducing the negative effects of pollution and blue light-induced skin damage.

For example, researchers conducted a study to see if topical Synastol® TC could protect against and repair pollution-induced skin damage. The results showed that Synastol® TC offered longer-lasting and more efficient neutralization of reactive oxygen species (ROS) compared to tocopherol. Synastol® TC also offered significant improvements in skin texture, hydration, tone, firmness, and radiance, which validated its ability to restore and prevent skin damage caused by environmental pollution.

Another study determined whether an oral form of Synastol® TC could regulate the skin’s sebum production and reduce wrinkles. Researchers and dermatologists discovered that subjects who received the TC capsules had a reduction in forehead sebum excretion rate, cheek erythema, and facial wrinkles over the course of eight weeks compared to subjects who received the placebo capsules.

When you need an effective ingredient with anti-aging benefits, consider Synastol® TC for your formulation.

5. Hydra Synol® DOI: A Smart Lipophilic Skin Hydrator & Barrier Builder

Hydra Synol® DOI (INCI: Isosorbide Dicaprylate) is a plant-based ingredient that intelligently hydrates and defends the skin. It’s also a natural and biodegradable alternative to phenyl trimethicone for ultimate hair shine.

Researchers studied Hydra Synol® DOI’s ability to improve water homeostasis and epidermal barrier function in the skin. They compared 2% of Hydra Synol® DOI lotion with 2% glycerol lotion. The result? Hydra Synol® DOI proved to be the superior skin hydration solution. Researchers also found that Hydra Synol® DOI positively modulated the genes involved with maintaining skin structure and function, leading to better clinical outcomes.

Incorporate Hydra Synol® DOI into your formulation when you want a versatile ingredient that offers unmatched skin hydration and defense.

6. VitaSynol® C: Stable & Bioavailable Vitamin C

VitaSynol® C (INCI: Tetrahexyldecyl Ascorbate) is a stable, oil-soluble Vitamin C ester. Upon Vitamin C release, VitaSynol® C effectively mitigates cellular damage, scavenges reactive oxygen species (ROS), and inhibits UV-induced melanogenesis. For achieving the best results, VitaSynol® C should be paired with an antioxidant like Synoxyl® AZ or Sytenol® A.

Combining VitaSynol® C with Synoxyl® AZ helps to stabilize the formulation and improve collagen production and antioxidant effects. This development brings VitaSynol® C significantly closer to realizing its complete potential as an active component in topical formulations.

7. Synoxyl® HSS: The Solution to Making Hawaii-Compliant Sunscreens

Synoxyl® HSS (INCI: Trimethoxybenzylidene Pentanedione) is a patented ingredient that’s an SPF booster for both organic and inorganic sunscreens. It’s the ideal ingredient for creating sunscreens without octocrylene and oxybenzone, which many beauty brands are avoiding due to the possible human health and environmental risks. By decreasing the amount of sunscreens used, formulas become much more cost-effective with the addition of Synoxyl® HSS.

Researchers incorporated Synoxyl® HSS into a broad-spectrum sunscreen formulation that included avobenzone, a chemical compound known for effectively absorbing a broad range of ultraviolet a (UVA) wavelengths. They discovered Synoxyl® HSS is an efficacious photostabilizer that boosts in-vivo SPF by >50% for organic and inorganic sunscreens.

Use Synoxyl® HSS in your formula to enhance the efficacy of sunscreens while yielding cost savings during formulation.

8. Synovea® EL: A Synergist With Multiple Skin Benefits

Synovea® EL (INCI: Ethyl Linoleate) is a neutral, lipid-soluble stable form of linoleic acid with various benefits:

Maintains stratum corneum acidity
Protects barrier function
Decreases sebaceous gland activity
Regulates follicular keratinization
Inhibits post-inflammatory hyperpigmentation
Reduces skin pigmentation

Synovea® EL diminishes the activity of genes linked to cell-cell adhesion, skin development, and inflammatory response. This makes Synovea® EL the perfect ingredient for acne prevention, skin rejuvenation, and skin texturization.

9. Asyntra® D-Stress: Destress Your Skin

Asyntra® D-Stress (INCI: Isosorbide Dicaprylate and Bakuchiol and Ethyl Linoleate) is a plant-based, patent-pending ingredient that can work solo or in tandem with CBD and hemp oil. Its healing effects reduce the presence of the stress-inducing marker “cortisol,” a driver of inflammation. Simultaneously, Asyntra® D-Stress reinforces the skin’s barrier function, resulting in a visibly smoother, well-hydrated, and more radiant complexion.

One study evaluated the effects of cannabidiol (CBD) in keratinocytes (KCs) and compared them with Asyntra® D-Stress, Sytenol® A, and Synovea® EL. Sytenol® A and Synovea® EL are two key components in Asyntra® D-Stress, and researchers wanted to see how the ingredients performed individually versus in combination. It was proven that there was synergy between the two ingredients, resulting in Asyntra® D-Stress being more effective than Sytenol® A and Synovea® EL alone at:

Enhancing the bliss molecule anandamide by reducing degradation enzymes and transport proteins
Inhibiting downstream inflammatory mediators such as TNF, COX-2, and type 1 IFN
Reducing cortisol and IL-8 secretion in reconstituted human epidermis skin, which was not observed with CBD alone
Providing compensatory effects to buffer against loss of keratinocyte differentiation and protect against skin barrier compromise

These findings prove that Asyntra® D-Stress is a safe and effective alternative to CBD in your formulation.

10. Synactin® AC: 5-in-1 Solutions in Mitigating Acne-Affected Skin

Synactin® AC (INCI: Caprylic/Capric Triglycerides and Ethyl Linoleate and Hexylresorcinol) is a synergistic blend that targets acne-affected skin. It mitigates all five key acne targets:

Hyper-keratinization
Bacterial population
Sebum control
Inflammation
Pigmentation

Synactin® AC was found to help significantly reduce the appearance of acne lesions and improve skin texture. It also proved to greatly reduce skin redness.

When you want to provide consumers with an effective anti-acne product, consider adding Synactin® AC to your formulation for successful results.

Conclusion

With a keen focus on efficacy, today’s beauty enthusiasts demand skincare products that promise results and are grounded in science.

This demand has given rise to a new era of beauty brands that are dedicated to incorporating science-backed active ingredients into their formulations, ensuring their products deliver on their promises.

Refine your skincare products with clinically proven active ingredients from Sytheon. Try one of our ingredients in your formulation when you request a sample.

Sep 7, 2023

Sytheon Takes on Suppliers’ Day in Singapore: Speaking Session & Partner Booth

Sytheon, a global supplier of unique and multifunctional active ingredients, is thrilled to announce its participation at this year’s Suppliers’ Day in Singapore.

Suppliers’ Day in Singapore is scheduled for September 13-15, 2023. The first two days will take place on Zoom and include a webinar on September 14 at 10:20 AM from Marie Delasson, Sytheon’s Asia Pacific General Manager. Her presentation, “A New Dawn for Skin Care: How to Stop Aging Before It Happens,” will explore how certain skincare ingredients can counteract aging and reverse key signs of photo-damaged skin. One example is Synoxyl® AZ (INCI: Acetyl Zingerone), a multi-targeted molecule that elevates biological skin defenses and prevents the signs of aging due to natural and environmental stressors.

“It’s an honor to speak at Suppliers’ Day in Singapore,” said Delasson. “I look forward to meeting with industry professionals and sharing insights into how antiaging skincare ingredients such as Synoxyl® AZ can revolutionize the industry by mitigating the effects of aging.”

The last day will be a physical exhibition at the Marriot Tang Plaza Hotel, where Sytheon will be sharing a booth with its local partner, DKSH. Stop by our booth to discuss our active ingredients and learn how you can incorporate them into your products.

Jul 28, 2023

Clinical Study: Synastol® TC (Terminalia Chebula Fruit Extract) Supplementation Reduces Wrinkles

In a recent article published in the ***Journal of Clinical Medicine, Synastol® TC (INCI: Terminalia Chebula* Fruit Extract) is the focus of a double-blind study to determine if oral TC fruit extract supplementation can regulate the skin’s sebum production and reduce wrinkles.**

PARSIPPANY, NJ – Terminalia Chebula (TC) is a medicinal plant commonly used in Ayurveda and herbal remedies that has antioxidant, anti-inflammatory and antibacterial properties. In addition to applying TC topically on the skin for cosmetic benefits, researchers and dermatologists were interested in the effects TC would have on the skin via oral supplementation.

To investigate these potential effects, researchers conducted a double-blind, placebo-controlled clinical study using Synastol® TC (INCI: Terminalia Chebula Fruit Extract). The objective was to determine whether such supplementation could regulate sebum production and reduce the appearance of wrinkles.

The study included 38 healthy females between the ages of 25 and 65 who were given either a placebo capsule or a 250 mg capsule of Synastol® TC twice daily for eight weeks.

The results are as follows:

The subjects who took the TC capsules showed a 33% decrease in forehead sebum excretion rate compared to an increase of 29% in the ones who took the placebo capsules at eight weeks (p<0.01).
Cheek erythema showed a statistically significant decrease after eight weeks of taking the TC capsules compared to those who took the placebo.
The interventional group saw a statistically significant decrease in facial wrinkles compared to the placebo group as well.

In conclusion, Synastol® TC oral supplementation is an effective way to reduce facial sebum and improve the appearance of wrinkles.

To access the article, click here.

Also featured in GCI and Cosmetics & Toiletries.

About Sytheon

Sytheon is an innovative research-focused company committed to developing high-performance active ingredients for the personal care industry. Inspired by nature, all of Sytheon’s ingredients have been scientifically and clinically validated to improve the health and beauty of the skin.

Visit our website: www.sytheonltd.com

Jul 20, 2023

4 Cosmetic Effects of Synoxyl® AZ (Acetyl Zingerone)

Everyone is exposed to environmental pollutants and ultraviolet (UV) rays, which can lead to oxidative stress and skin damage. That’s why beauty brands aim to incorporate ingredients that can prevent and repair these negative effects on the skin. One such ingredient is Synoxyl® AZ (INCI: Acetyl Zingerone).

What Is Synoxyl® AZ (INCI: Acetyl Zingerone)?

Synoxyl® AZ (AZ) is an antiaging molecule specifically developed to combat environmental pollutants and stressors that contribute to skin damage. Its innovative composition aims not only to prevent signs of aging but also to actively repair existing damage. In addition to the extrinsic factors, AZ goes above and beyond standard capabilities by also targeting the intrinsic factors that are involved in the skin’s aging process.

Intrinsic factors encompass the natural aging process that occurs within our bodies over time. The skin naturally undergoes changes such as reduced collagen, proteoglycan and ECM glycoprotein production, increased generation of metalloprotease enzymes, decreased cellular turnover and diminished moisture retention which all can lead to the development of wrinkles, sagging skin and a loss of radiance and firmness.

Extrinsic factors, on the other hand, stem from external influences that impact the skin, often accelerating the aging process. Reactive oxygen species (ROS), harmful UV radiation, lifestyle choices and stress can all contribute to the formation of fine lines, hyperpigmentation, uneven skin tone and poor complexion.

Synoxyl® AZ, with its unique multi-targeted approach, tackles both intrinsic and extrinsic factors comprehensively. It acts as a shield against environmental aggressors by protecting and repairing the skin from the damaging effects of ROS and inflammation. Simultaneously, it penetrates deep into the skin, working to stimulate collagen and many other ECM protein syntheses, to promote cellular renewal and to boost the skin’s natural moisture retention abilities.

By addressing these underlying causes, Synoxyl® AZ offers a variety of cosmetic advantages. Let’s explore them now.

4 Cosmetic Effects of Synoxyl® AZ (AZ)

1. Omni-Antioxidant Properties

Topically applied antioxidants can help the skin efficiently manage the overproduction of ROS that commonly occurs from daily exposure to environmental stressors, especially solar radiation and air pollution.

The term omni-antioxidant has been coined to define antioxidants that exhibit durable chemical and photochemical stability coupled with the long-lasting capacity to function through multiple pathways to manage excess ROS levels.

ROS Neutralizer

What makes omni-antioxidants unique from conventional antioxidants is their ability to efficiently neutralize all of the most reactive species of ROS that form within the skin, including hydroxyl and peroxyl radicals, singlet oxygen species and peroxynitrite. Omni-antioxidants can also neutralize ROS before it induces skin damage.

Chelators, Physical Quenchers & Oxidase Enzyme Inhibitors

Another differentiator is that omni-antioxidants can prevent ROS formation within the skin by acting as a chelator, physical quencher or inhibitor of key ROS-generating enzymes.

Chelators inhibit the Fenton reaction as an important source of hydroxyl radicals by binding metal ions (iron and copper) selectively to disrupt their interaction with hydrogen peroxide.
Physical quenchers intercept the skin’s molecules after they absorb solar radiation, preventing the formation of ROS. Rather than the sacrificial nature of conventional antioxidants, physical quenchers act in a non-sacrificial manner so they can continue working the entire time the skin is exposed to the sun.
Oxidase Enzyme Inhibitors work to hinder or impede ROS activity. An omni-antioxidant serves as an inhibitor of NADPH oxidase and nitric oxide synthase that respectively produce superoxide anion and nitric oxide, which are important precursors to more reactive ROS (i.e., hydrogen peroxide, hydroxyl and peroxyl radicals, and peroxynitrite).

Therefore, an antioxidant qualifies as an omni-antioxidant if it functions as an efficient neutralizer, chelator, physical quencher and oxidase enzyme inhibitor that can manage the production of excess ROS with maximum proficiency. Currently, AZ is the only antioxidant that satisfies all of the requirements of omni-antioxidant classification.

2. Skin Damage Reduction

Combined exposure to ROS, environmental pollutants and blue light can have a synergistic effect intensifying the damage caused to the skin. The oxidative stress induced by these external factors can lead to chronic inflammation, DNA damage and degradation of the skin’s support structure which subsequently contributes to the development of wrinkles, pigmentation, skin redness and premature aging.

After eight weeks in a double-blind, placebo-controlled clinical study, AZ showed a significant reduction in:

Average wrinkle severity
Total wrinkle volume
Pigment intensity
Redness intensity

In addition, after daily use of the lotion containing AZ, the participants reported it was well-tolerated with no negative side effects such as itching or burning.

3. Skin Rejuvenation

The skin microbiome refers to the community of microorganisms, including bacteria, fungi and viruses, that reside on the skin’s surface. A diverse and balanced microbiome is considered crucial for maintaining skin health. A skin-friendly bacterium called Staphylococcus epidermidis is a common bacterium found on human skin, and it is generally regarded as a beneficial species that helps protect the skin from harmful pathogens.

The state of the skin microbiome can influence various skin conditions, including acne, eczema, and psoriasis. Acne and eczema are often associated with an overgrowth of opportunistic pathogen Staphylococcus aureus while psoriasis is characterized by overgrowth of S. aureus and certain fungal pathogens. Additionally, an imbalance in the immune response and skin barrier function is observed in all three diseases.

AZ balances the diversity of the skin microbiome and stimulates the growth of Staphylococcus epidermidis by >20%. By promoting the presence of this beneficial bacterium, AZ maintains the optimal skin microbiome that nurtures healthy skin and aids in the prevention of these various skin problems. Implementing AZ into any skincare formulation can help customers improve skin health by sustaining a diverse and healthy microbiome.

4. Skin Defense

L-ascorbic acid (AA), also known as vitamin C, is a water-soluble vitamin and a powerful exogenous antioxidant that’s essential for maintaining healthy, youthful skin. AA helps to boost the skin’s barrier function, which fortifies its defenses against ROS production caused by UV rays and environmental pollutants.

One popular stabilized AA-ester used in cosmetic formulations is Tetrahexyldecyl Ascorbate (THDC, VitaSynol® C). Its oil-soluble nature allows it to effectively penetrate the lipid-rich outer layer of the skin, which can enhance its bioavailability and potential efficacy, unlike other forms of vitamin C.

Unfortunately, THDC is prone to degradation from O₂, an entity of ROS that often forms within oxidatively damaged skin. Therefore, a stabilizing antioxidant needs to accompany THDC to prolong its effectiveness. Traditional antioxidants can readily degrade before being able to scavenge these ROS. However, Synoxyl® AZ is a photostable omni-antioxidant that has been proven to quench O₂ and help preserve the chemical integrity of THDC.

One study found that Synoxyl® AZ extended the existence of THDC from 6.4% to 81% and from 0% to 75% after exposure to O₂ for 2 and 10 minutes, respectively. Increasing the lifespan of THDC can improve the amount of AA available in the skin. Adding AZ into skincare formulas with THDC helps consumers take advantage of the antiaging and skin-brightening effects of AA.

Conclusion

Synoxyl® AZ (INCI: Acetyl Zingerone) is a versatile active ingredient that unlocks various cosmetic effects for the skin. It serves as an omni antioxidant, reduces skin damage, rejuvenates skin, and strengthens skin defense. All these properties help make the skin look more youthful while protecting it from the negative effects of ROS and UV rays.

Sytheon is a research-backed developer of high-performance active ingredients – including Synoxyl® AZ. To test Synoxyl® AZ with your formulation, request a sample.

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The Clinically Backed Actives Your Customers Have Been Waiting For

Today’s personal care consumers are vigilant about the ingredients used in their favorite skincare products. They want to know exactly what’s in the product and how well it will work. To meet these needs, beauty brands must use active ingredients that are scientifically proven to perform.

Why Science Matters in Skincare Active Ingredients

10 Active Ingredients that Will Enhance Your Skincare Formulation

1. Sytenol® A: The Best Bakuchiol

2. Synoxyl® AZ: Microbiome Friendly, 24/7 Prevention & Repair of Skin Damage

3. Synovea® HR: The Gold Standard in Skin Brightening & Even Toning

4. Synastol® TC: The Holistic Solution to Pollution & Blue Light-Induced Skin Damage With Anti-Aging Benefits

5. Hydra Synol® DOI: A Smart Lipophilic Skin Hydrator & Barrier Builder

6. VitaSynol® C: Stable & Bioavailable Vitamin C

7. Synoxyl® HSS: The Solution to Making Hawaii-Compliant Sunscreens

8. Synovea® EL: A Synergist With Multiple Skin Benefits

9. Asyntra® D-Stress: Destress Your Skin

10. Synactin® AC: 5-in-1 Solutions in Mitigating Acne-Affected Skin

Conclusion

Sytheon, a global supplier of unique and multifunctional active ingredients, is thrilled to announce its participation at this year’s Suppliers’ Day in Singapore.

In a recent article published in the Journal of Clinical Medicine, Synastol® TC (INCI: Terminalia Chebula Fruit Extract) is the focus of a double-blind study to determine if oral TC fruit extract supplementation can regulate the skin’s sebum production and reduce wrinkles.

What Is Synoxyl® AZ (INCI: Acetyl Zingerone)?

4 Cosmetic Effects of Synoxyl® AZ (AZ)

1. Omni-Antioxidant Properties

ROS Neutralizer

Chelators, Physical Quenchers & Oxidase Enzyme Inhibitors

2. Skin Damage Reduction

3. Skin Rejuvenation

4. Skin Defense

Conclusion

The versatility of Synoxyl® AZ embodies the definition of a “next generation” skincare ingredient to maintain and augment skin’s beauty and health throughout life.

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Backed Actives Your Customers Have Been Waiting For

In a recent article published in the ***Journal of Clinical Medicine, Synastol® TC (INCI: Terminalia Chebula* Fruit Extract) is the focus of a double-blind study to determine if oral TC fruit extract supplementation can regulate the skin’s sebum production and reduce wrinkles.**

**The versatility of Synoxyl® AZ embodies the definition of a “next generation” skincare ingredient to maintain and augment skin’s beauty and health throughout life.**