Anti-aging Restorative

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As we age, skin loses its elasticity and becomes thin, weak and prone to wrinkles and hyperpigmentation. The loss of skin thickness due to the lack of collagen support, the aging skin or aged skin looks pale and lacks elasticity. These two properties are the hallmarks of wrinkles and creases. How can this be reversed? The main goal of anti-aging products is to decrease and eventually eliminate the appearance of fine lines and wrinkles and provide even-toning effects. The way to achieve this goal is to prevent skin from further damage, maintaining mainly the integrity of extra cellular matrix (ECM), dermal-epidermal junction (DEJ) areas, controlling glycation and preserving skin hydration.

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Synoxyl® AZ (INCI: Acetyl Zingerone) Use level: 0.5 to 2%

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A breakthrough multi-targeted anti-aging active - Stops aging before it happens; Nature inspired design based on structural modification of Zingerone; Maintains extracellular matrix integrity by modulating collagens, elastins and many other ECM proteins, integrins (provides bridges for cell-cell & cell-extracellular matrix interactions) & laminins (key component of the basement membrane & vital for the maintenance & survival of tissues); Maintains matrix protein homeostasis by stimulating transforming growth factor β (TGF-β). Clinically proven to reduce wrinkle severity by over 25% and wrinkle volume by about 30% in just 4-week treatment of 1% Synoxyl® AZ lotion.

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Sytenol® A (INCI: Bakuchiol) Use level: 0.5 to 1%

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Sytenol® A is the first natural alternative to Retinol without having any of the negatives associated with retinol. It is photochemically and hydrolytically stable and can be used during the day. Sytenol® A is a highly purified meroterpene of natural origin having no structural resemblance to retinoids. Multiple comparative studies revealed Sytenol® A to be true alternative to retinol. Retinol-like functionality was further confirmed for type I, III and IV collagens and aquaporin 3 by ELISA and histochemistry. Clinical study showed significant improvement in lines and wrinkles, pigmentation, elasticity, firmness and overall reduction in photo-damage without usual retinol-associated undesirable effects.

Commercial use of Sytenol® A in a wide-variety of skin care and treatment products has begun and is expanding. Sytenol® A has now become a sought after ingredient for developing broad-spectrum anti-aging products.

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Synastol® TC (INCI: Terminalia chebula fruit extract) Use level: 0.5 to 1%

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Synastol® TC is a standardized edible fruit extract of Terminalia chebula which is obtained by using a water-based process. The product has been standardized against total hydrolysable tannins: ≥50%, Chebulinic acid: ≥20% and Chebulagic acid: ≥10%. Anti-aging property of Synastol® TC is due to its collagen boosting & preservation by six distinct pathways and inhibition of hyaluronic acid degradation by hyaluronidase. Clinically, Synastol® TC has been demonstrated to mitigate multiple signs of aging – fine lines, wrinkles, dark circles around the eyes and normalizing yellowish skin caused by high level of glycation. Globally approved. Suggested use level

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Asyntra® C3S Use level: 2 to 4%
(INCI: Water, Lecithin, Dipalmitoyl Hydroxyproline, Phenoxyethanol, β-Sitosterol, Linoleic acid, Tocopherol, Sodium Ascorbate & Mannitol)

Asyntra® C3S is a liposomal delivery system designed specifically to rebuild extracellular matrix proteins. Unique bi-pyramidal structure is the key to this property. Use of this ingredient boosts collagen III selectively with no effect on matrix metalloprotease activity. It provides improvement in skin elasticity and also a skin rejuvenator. Anti-aging benefits have been validated by consumer testing.

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HydraSynol IDL (INCI: Isosorbide Disunflowerseedate) Use level: 2 to 4%

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No matter what the skin concern is, improving the appearance and function of the skin comes down to maintaining a healthy barrier; IDL is a stable & novel isosorbide diesters of sunflower fatty acids; Easy to use liquid; Works by stimulating SASPase, filaggrin and other genes/proteins thereby re-establishing skin function & integrity; Improves skin radiance due to modulating kalikreins (KLKs, natural exfoliator); Clinically shown to provide itch relief and improves skin hydration, skin barrier and appearance.

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