Synoxyl® AZ

Microbiome Friendly 24/7 Prevention & Repair of Skin Damage

Acetyl Zingerone is a multi-targeted antiaging molecule designed to counteract aging before it happens and to reverse key signs of photo-damaged skin. It prevents skin damage and nurtures skin’s own ability to maintain the integrity of the ECM for optimal health and appearance throughout life.

Key attributes:

  1. Omni Antioxidant- scavenges/quenches reactive species & selectively chelates iron – First-in-the Industry
  2. Reduces both immediate & delayed skin damage (↓CPDs) First-in-the Industry
  3. Photochemically stable antioxidant in contrast to many conventional antioxidants
  4. Placebo-controlled clinical studies revealed significant improvement in skin defense & reduction in wrinkle, pigmentation and skin redness in photo-aged skin without using sunscreens
  5. Balances skin microbiome diversity and stimulates skin friendly Staphylococcus epidermidis by >20%.

REACH registered. Patented product.

Synoxyl® AZ thus provides a translational step forward towards development of a more efficacious molecule to treat or prevent the consequences of intrinsic and extrinsic skin aging.

Product Summary

INCI
  • Acetyl Zingerone
Clinical studies
  • Significant reduction in wrinkle severity (>25%) & volume in 4 weeks as compared to placebo
  • Significant reduction in pigment intensity (25%) in 4 weeks as compared to placebo
  • Maintains skin microbiome diversity with 25% increase in Staph epidermidis
  • Significant reduction (40%) in skin redness induced by UV challenge test
Characteristics
  • All-in-one – Antioxidant, Quencher & Selective Chelator
  • Reduces both immediate and delayed dark skin damage
  • Photochemically stable antioxidant as compared to conventional antioxidants
  • Elevates biological skin defenses
Use Level
  • 0.5 to 1%
Origin
  • Organic Synthesis
synoxyl-az

Applications

After Sun:

Photo-aging Repair

Anti-pollution:

Skin Detox

Sun Preparation:

Skin Protection

Publications

Synoxyl® AZ

INCI: Acetyl Zingerone

  • T Meyer, RK Chaudhuri, Omni Antioxidant: Acetyl Zingerone scavenges/quenches reactive species, selectively chelates iron, C&T, October 2020
  • S Dhaliwal, I Rybak, A Pourang, W Burney, K Haas, S Sandhu, R Crawford, R Sivamani, Randomized Double-Blind Vehicle Controlled Study of the Effects of Topical Acetyl Zingerone on Photoaging, J Cosmetic Dermatology, 2020 May 5, doi: 10.1111/jocd.13464.
  • WR Swindell, K Bojanowski, RK Chaudhuri, A zingerone analog, acetyl zingerone, bolsters matrisome synthesis, inhibits MMPs, and represses IL-17A target gene expression, J Invest Dermatol, 140:602-614, 2020.
  • RK Chaudhuri, T Meyer, S Premi, D Brash, Acetyl Zingerone: An efficacious multifunctional ingredient for continued protection against on-going DNA damage in melanocytes after sun exposure ends, International International J Cosmetic Science, 42(1):36-45, 2020, . Open access.

Other Ingredients