Anti-aging Preventive

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As we age, skin loses its elasticity and becomes thin, weak and prone to wrinkles and hyperpigmentation. The loss of skin thickness due to the lack of collagen support, the aging skin or aged skin looks pale and lacks elasticity. These two properties are the hallmarks of wrinkles and creases. How can this be reversed? The main goal of anti-aging products is to decrease and eventually eliminate the appearance of fine lines and wrinkles and provide even-toning effects. The way to achieve this goal is to prevent skin from further damage, maintaining mainly the integrity of extra cellular matrix (ECM), dermal-epidermal junction (DEJ) areas, controlling glycation and preserving skin hydration.

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Sytenol® A (INCI: Bakuchiol) Use level: 0.5 to 1%

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Targeting skin concerns early on can effectively prevent damage to the skin’s surface and improve skin quality. Slowing down the aging process can be achieved by using Sytenol® A due to its broad-spectrum antioxidant property and boosting antioxidant defense to limit direct oxidative damage to skin and also due to its anti-inflammatory and matrix metalloprotease inhibitory activities. It has a strong lipid peroxidation inhibition activity which is 60-foldmore powerful than natural tocopherol. Clinically, skin protection property of Sytenol® A (without using sunscreens) has been demonstrated by the reduction of sun-induced skin erythema.

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Synastol® TC (INCI: Terminalia chebula fruit extract) Use level: 0.5 to 1%

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Synastol® TC is a standardized edible fruit extract of Terminalia chebula which is obtained by using a water-based process. Synastol® TC provides the first natural solution in mitigating glycation by reversing as well as inhibiting is formation. It controls oxidative stress by quenching five major radicals & non-radical and reduces formation of superoxide by inhibiting xanthine oxidase activity. It preserves matrix proteins by inhibiting matrix metalloprotease activity and controls inflammation by reducing LOX and COX activities. Globally approved.

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Synovea® HR (INCI: Hexylresorcinol) Use level: 0.5 to 1%

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Synovea® HR (HR) is a highly purified material (>99%, typically ranging from 99.5 to 99.9%) which is essentially free of resorcinol, a known skin irritant and is particularly suitable for topical applications. HR is perhaps one of, if not the, most studied and well-known alkylresorcinol. HR has a long and safe history of human use.

HR provides broad-spectrum multi-targeted skin protection by up-regulating antioxidant defense system - glutathione & glutathione enzymes. HR also has moderate glycation inhibitory activity and has a strong NF-κB inhibitory activity which is 8 to 16-fold more effective than Resveratrol and Curcumin, respectively. Globally approved.

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HydraSynol IDL (INCI: Isosorbide Disunflowerseedate) Use level: 2 to 4%

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HydraSynol IDL, a patented product, prepared by reacting isosorbide (obtained from corn) and fatty acids (from sun flower seed oil) using an eco-friendly process. HydraSynol IDL is novel structurally and a stable version of linoleic acid (LA) and provides all the benefits of LA and more.

HydraSynol IDL defends skin barrier by dual pathways – building antioxidant shield by boosting Small Proline-Rich Proteins (SPRPs) and by inhibiting up-stream pro-inflammatory mediators, demonstrated by ex-vivo study.

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